Temperature sensing across species.
Temperature sensing across species.
复制标题
跨物种的温度传感。
DOI：
10.1007/s00424-006-0199-6
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
McKemy,DavidD
中科院分区：
文献类型：
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作者：
McKemy,DavidD
探测温度变化的能力是每个物种的基本感觉机制，并为生物体提供了对环境的详细视图。本综述的重点是物种间热感觉的神经元和分子底物，重点是广泛用于研究感觉信号的三种强大的模型系统：线虫、果蝇和实验室小鼠。线虫迁移到适合它们生存的热气候，这一行为主要是通过一个感觉神经元来调节的。此外，线虫根据它们先前的经验“学习”寻找这个温带，这是一种强大的学习和记忆模型。果蝇幼虫也喜欢选择最适合生长的热区，并且还发展了强有力的机制来避免不利的条件。在哺乳动物中，热感觉的转导机制已经被确定，主要是因为自然产生的植物产品能唤起不同的温度变化的心理生理感觉。更值得注意的是，对哺乳动物和果蝇中分子传感器的阐明，证明了不同物种中温度感觉分子介质的守恒性。
The ability to detect changes in temperature is a fundamental sensory mechanism for every species and provides organisms with a detailed view of the environment. This review focuses on what is known of the neuronal and molecular substrates for thermosensation across species, focusing on the three robust model systems extensively used to study sensory signaling, the nematodeCaenorhabditis elegans, the fruit flyDrosophila melanogaster, and the laboratory mouse. Nematodes migrate to thermal climes that are amenable to their survival, a behavior that is regulated primarily through a single sensory neuron. Additionally, nematodes “learn” to seek out this temperate zone based upon their prior experience, a robust model of learning and memory.Drosophilalarvae also prefer select thermal zones that are optimal for growth and have also developed vigorous mechanisms to avoid unfavorable conditions. In mammals, the transduction mechanisms for thermosensation have been identified primarily due to the fact that naturally occurring plant products evoke distinct psychophysical sensation of temperature change. More remarkably, the elucidation of the molecular sensors in mammals, along with those inDrosophila, has demonstrated conservation in the molecular mediators of temperature sensation across diverse species.