Carbazole alkaloids as new cell cycle inhibitor and apoptosis inducers from Clausena dunniana Levl.
Carbazole alkaloids as new cell cycle inhibitor and apoptosis inducers from Clausena dunniana Levl.
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DOI：
10.1080/1028602021000049041
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发表时间：
2002-12-01
影响因子：
1.7
通讯作者：
Yao, XS
中科院分区：
文献类型：
--
作者：
Cui, CB;Yan, SY;Yao, XS
从广东黄皮（ClausenadunnianaLevl.）通过生物测定引导的分离程序，并通过光谱方法鉴定。化合物1-5表现出生长抑制活性（1，IC 50 25 μ g/ml）对人纤维肉瘤HT-1080细胞和细胞周期M期抑制（2，MIC 0.78 μ g/ml）和凋亡诱导（2）MIC为1.56 μ g/ml，（3）MIC为25 μ g/ml，（4）MIC为20 μ g/ml，（5）MIC为20 μ g/ml。5，MIC 30 μ g/ml）对小鼠tsFT 210细胞的活性，和2-5提供了咔唑生物碱作为新的细胞周期抑制剂和凋亡诱导剂的第一个实例。
Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (14) and bicyclomahanimbine (5), were isolated for the first time front Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1-5 showed growth inhibitory activity (1, IC50 25 mug/ml) on human fibrosarcoma HT-1080 cells and cell cycle M-phase inhibitory (2, MIC 0.78 mug/ml) and apoptosis inducing (2, MIC 1.56 mug/ml; 3, MIC 25 mug/ml; 4, MIC 20 mug/ml; 5, MIC 30 mug/ml) activities on mouse tsFT210 cells, respectively, and 2-5 provided the first examples of carbazole alkaloids as new cell cycle inhibitors and apoptosis inducers.