Burden of fungal infections in Senegal
Burden of fungal infections in Senegal
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DOI：
10.1111/myc.12381
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发表时间：
2015-10-01
期刊：
影响因子：
4.9
通讯作者：
Denning, David W.
中科院分区：
文献类型：
--
作者：
Badiane, Aida S.;Ndiaye, Daouda;Denning, David W.
塞内加尔结核病发病率高，艾滋病毒血清阳性率低，本研究报告了曲霉菌瘤、危及生命的真菌感染、皮肤真菌病和足菌肿。确定了所有报告塞内加尔真菌感染率的已发表流行病学论文。在没有数据的地方，我们使用特定的高危人群和真菌感染频率来估计全国的发病率或患病率。结果显示，25%的儿童患有头癣，约有150万。大约有191000名塞内加尔妇女每年4次复发性阴道鹅口疮。我们估计了685例结核病后慢性肺曲霉菌病（CPA）的发病病例和2160例患病病例。成人哮喘患病率从3.2%到8.2%不等（平均5%）; 9976名成人患有过敏性支气管肺曲霉菌病（ABPA），13168名患有严重哮喘伴真菌致敏（SAFS）。在估计的59000例HIV阳性患者中，366例发展为隐球菌性脑膜炎，1149例发展为肺孢子虫肺炎，1946例发展为食管念珠菌病，其中口腔念珠菌病（53%）和皮肤真菌病（16%）是常见的。自2008-2010年以来，诊断出113例足菌肿。总之，我们估计塞内加尔有1743507（12.5%）人患有真菌感染，不包括口腔念珠菌病、真菌性角膜炎、侵袭性念珠菌病或曲霉病。应纠正诊断和治疗方面的缺陷，以便进行流行病学研究。
Senegal has a high rate of tuberculosis and a low HIV seropositivity rate and aspergilloma, life-threatening fungal infections, dermatophytosis and mycetoma have been reported in this study. All published epidemiology papers reporting fungal infection rates from Senegal were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in each to estimate national incidence or prevalence. The results show that tinea capitis is common being found in 25% of children, similar to 1.5million. About 191000 Senegalese women get recurrent vaginal thrush, 4 times annually. We estimate 685 incident cases of chronic pulmonary aspergillosis (CPA) following TB and prevalence of 2160 cases. Asthma prevalence in adults varies from 3.2% to 8.2% (mean 5%); 9976 adults have allergic bronchopulmonary aspergillosis (ABPA) and 13168 have severe asthma with fungal sensitisation (SAFS). Of the 59000 estimated HIV-positive patients, 366 develop cryptococcal meningitis; 1149 develop Pneumocystis pneumonia and 1946 develop oesophageal candidiasis, in which oral candidiasis (53%) and dermatophytosis (16%) are common. Since 2008-2010, 113 cases of mycetoma were diagnosed. In conclusion, we estimate that 1743507 (12.5%) people in Senegal suffer from a fungal infection, excluding oral candidiasis, fungal keratitis, invasive candidiasis or aspergillosis. Diagnostic and treatment deficiencies should be rectified to allow epidemiological studies.