Reaginic hypersensitivity in ulcerative colitis
Reaginic hypersensitivity in ulcerative colitis
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DOI：
10.1136/gut.13.11.903
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发表时间：
1972-11
期刊：
影响因子：
24.5
通讯作者：
D. Jewell;S. Truelove
中科院分区：
文献类型：
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作者：
D. Jewell;S. Truelove
溃疡性结肠炎的反应性超敏反应与牛奶蛋白过敏以及特应性哮喘、花粉热和湿疹的发生率有关。皮内试验经常呈阳性，特别是对酪蛋白，但结果与健康人和克罗恩病、扩张不足和肠易激综合征患者组的结果没有不同。没有发现循环中的针对牛奶蛋白的IgE特异性抗体。溃疡性结肠炎(15.7%)和克罗恩病(13.3%)患者的特应性疾病发生率高于对照组(1.2%)。结论是，如果对牛奶蛋白的过敏是溃疡性结肠炎发病的一个因素，它不是由Reaginic抗体介导的。然而，特应性反应的频繁发生可能表明，即使这种机制不适用于牛奶蛋白，也容易产生反应性反应。
Reaginic hypersensitivity in ulcerative colitis has been investigated in respect of a hypersensitivity to the cow's milk proteins and the frequency of atopic asthma, hay fever, and eczema. Intradermal tests were frequently positive, especially to casein, but the results did not differ from those found in healthy individuals and in groups of patients with Crohn's disease, hypolactasia, and the irritable colon syndrome. No circulating IgE-specific antibodies to the milk proteins were found. An increased frequency of atopic diseases was found in patients suffering from ulcerative colitis (15·7%) and Crohn's disease (13·3%) compared with the findings in a control group (1·2%). It is concluded that, if an allergy to milk proteins is a factor in the pathogenesis of ulcerative colitis, it is not mediated by reaginic antibodies. It is possible, however, that the frequent occurrence of atopy indicates a susceptibility to develop reaginic responses even though this mechanism does not apply to the milk proteins.