Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population
Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population
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DOI：
10.1111/j.1440-1797.2010.01327.x
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发表时间：
2010-10
期刊：
影响因子：
2.5
通讯作者：
L. Qin;J. Lv;Xu-jie Zhou;P. Hou;Haizhen Yang;Hong Zhang
中科院分区：
文献类型：
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作者：
L. Qin;J. Lv;Xu-jie Zhou;P. Hou;Haizhen Yang;Hong Zhang
目的：最近，一些研究提供了令人信服的证据，在干扰素调节因子5（IRF5）基因多态性显着相关的系统性红斑狼疮（SLE）在几个群体。本研究的目的是探讨IRF5与中国人群狼疮肾炎的相关性，并分析rs2004640基因型与狼疮肾炎临床和病理表型的关系。
Aim: Recently, several studies have provided convincing evidence that polymorphisms in the interferon regulatory factor 5 (IRF5) gene were significantly associated with systemic lupus erythematosus (SLE) in several populations. The aim of this study was to investigate the association between IRF5 and lupus nephritis in a Chinese cohort and analyze the relationship between the rs2004640 genotype and the clinical and pathological phenotypes of lupus nephritis.