Role of TNFalpha in pulmonary pathophysiology.
Role of TNFalpha in pulmonary pathophysiology.
复制标题
DOI：
10.1186/1465-9921-7-125
复制
发表时间：
2006-10-11
影响因子：
5.8
通讯作者：
Mukherjee TK
中科院分区：
文献类型：
--
作者：
Mukhopadhyay S;Hoidal JR;Mukherjee TK
Tumor necrosis factor alpha (TNFα) is the most widely studied pleiotropic cytokine of the TNF superfamily. In pathophysiological conditions, generation of TNFα at high levels leads to the development of inflammatory responses that are hallmarks of many diseases. Of the various pulmonary diseases, TNFα is implicated in asthma, chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In addition to its underlying role in the inflammatory events, there is increasing evidence for involvement of TNFα in the cytotoxicity. Thus, pharmacological agents that can either suppress the production of TNFα or block its biological actions may have potential therapeutic value against a wide variety of diseases. Despite some immunological side effects, anti-TNFα therapeutic strategies represent an important breakthrough in the treatment of inflammatory diseases and may have a role in pulmonary diseases characterized by inflammation and cell death.
登录
查看更多内容
分类哮喘的细胞因子。
影响因子：
15.3
作者：
Drazen, JM;Arm, JP;Austen, KF
通讯作者：
Austen, KF
影响因子：
8.8
作者：
Borrelli, E;RouxLombard, P;Suter, PM
通讯作者：
Suter, PM
DOI：
10.1097/01.ta.0000200075.12489.74
发表时间：
2006-01-01
影响因子：
--
作者：
Coimbra, R;Melbostad, H;Hoyt, DB
通讯作者：
Hoyt, DB
DOI：
10.1165/ajrcmb.24.6.4228
发表时间：
2001-06-01
影响因子：
6.4
作者：
Corda, S;Laplace, C;Duranteau, J
通讯作者：
Duranteau, J
影响因子：
14.2
作者：
Borish, LC;Nelson, HS;Agosti, JM
通讯作者：
Agosti, JM