Spontaneous blink rates correlate with dopamine levels in the caudate nucleus of MPTP-treated monkeys
Spontaneous blink rates correlate with dopamine levels in the caudate nucleus of MPTP-treated monkeys
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DOI：
10.1006/exnr.1999.7093
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发表时间：
1999-07-01
影响因子：
5.3
通讯作者：
Redmond, DE
中科院分区：
文献类型：
--
作者：
Taylor, JR;Elsworth, JD;Redmond, DE
先前的研究表明，多巴胺能调节人类和非人类灵长类动物的眨眼率。阻断多巴胺（DA）D1或DA D2受体或多巴胺能神经毒素MPTP诱导的DA耗竭均降低猴的自发眨眼率。MPTP诱导的眨眼率降低可以通过给予完全有效的D1激动剂dihydrexidine来逆转，这也被发现在MPTP治疗的动物中具有显着的抗帕金森病作用。在正常动物中，D1和D2激动剂也可诱导眨眼率增加。在目前的研究中，我们已经调查是否眨眼率与DA或HVA和/或HVA的浓度：DA比率在特定的大脑区域MPTP治疗的猴子。此外，帕金森症的行为指标和眨眼率的严重程度之间的潜在关系进行了检查。我们发现：（1）眨眼率与尾状核腹内侧体（CD）吻侧部分的DA浓度显著正相关，与HVA：DA比值呈负相关，但与其他皮质下区域无关;（2）帕金森综合征的严重程度与眨眼率呈负相关。这些数据支持多巴胺能调节眨眼率，并表明，腹内侧区域的身体的CD可能是至关重要的参与调节眨眼率。(C)北京：科学出版社.
Previous studies have suggested a dopaminergic regulation of eye blink rates in human and nonhuman primates. Blockade of either dopamine (DA) D1 or DA D2 receptors or DA depletion induced by the dopaminergic neurotoxin MPTP both decrease spontaneous eye blink rates in monkeys. MPTP-induced decreases in blink rates can be reversed by administration of the full efficacy D1 agonist dihydrexidine, which has also been found to have dramatic antiparkinsonian effects in MPTP-treated animals. Increases in blink rates can also be induced by D1 and D2 agonists in normal animals. In the current study, we have investigated whether blink rates correlate with concentrations of DA or HVA and/or HVA:DA ratios in specific brain regions in MPTP-treated monkeys. Furthermore, the potential relationship between the severity of behavioral indices of parkinsonism and blink rates were examined. We found that (1) blink rates significantly correlate positively with concentration of DA and inversely with HVA:DA ratios in the rostral portion of the ventromedial body of the caudate nucleus (CD), but not other subcortical regions, and (2) that severity of parkinsonism was inversely correlated with blink rate. These data support a dopaminergic regulation of blink rate and suggest that the ventromedial region of the body of the CD may be critically involved in regulation of blink rate. (C) 1999 Academic Press.