First-episode non-affective psychosis in a total urban population: a 5-year follow-up
First-episode non-affective psychosis in a total urban population: a 5-year follow-up
复制标题
DOI：
10.1007/s001270170037
复制
发表时间：
2001-07-01
影响因子：
4.4
通讯作者：
Cullberg, J
中科院分区：
文献类型：
--
作者：
Svedberg, B;Mesterton, A;Cullberg, J
背景资料：本研究的目的是调查斯德哥尔摩三个集水区71例首发精神病（DSM-IV）患者（年龄18-45岁）的住院和门诊总人群的发病率、治疗和结局。方法：通过对病历、数据库的调查，以及医护人员和患者提供的信息进行分析。结果：发病率为每10万居民（18-45岁）34.8例，每10万居民（总人口）16.5例。60%的人被诊断患有精神分裂症综合征。在5年的随访中，73%的精神分裂症综合征组患者与47%的非精神分裂症组患者有病假养老金或长期病假。9%的精神分裂症患者和39%的非精神分裂症精神病患者被认为不需要治疗。在这些患者中，有三分之一的患者不依从药物治疗。7%的人从未接受过精神抑制药物治疗，所有这些人在5年的随访中都被评为生病。结论：治疗的首发精神病的发病率高于早期发现的，当专门门诊治疗的个人也包括在内。社会结果是负面的，即使在非精神分裂症组。不依从药物治疗和临床随访不足可能会使结果恶化。
Background: The aim of this study is to investigate incidence rates, treatment, and outcome of a total in- and outpatient population of 71 patients (of 18-45 years of age) treated for a first-episode psychosis (DSM-IV) in three catchment areas in Stockholm. Methods: The study is based on the investigation of records and databases and on information by staff members and patients. Results: The incidence rate was 34.8 per 100,000 inhabitants (aged 18-45 years) and 16.5 per 100,000 inhabitants (total population). Sixty percent were diagnosed with schizophrenia syndromes. At 5-year follow-up, 73% of the patients in the schizophrenia syndromes group versus 47% of the non-schizophrenia group had a sick pension or were on long-term sick leave. Nine percent of the schizophrenia patients and 39% of the non-schizophrenia psychosis patients were rated as not being in need of treatment. Non-compliance of medication was present in one-third of those patients prescribed neuroleptic medication. Seven percent had never received neuroleptic medication, all of whom were rated as ill at the 5-year follow-up. Conclusions: Incidence of treated first-episode psychosis is higher than has earlier been found, when exclusively outpatient treated individuals are also included. The social outcome is negative, even in the non-schizophrenia group. Non-compliance with medication and insufficient clinical follow-up may have worsened the results.