Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study
Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study
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DOI：
10.1136/bmjopen-2020-040286
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发表时间：
2020-01-01
期刊：
影响因子：
2.9
通讯作者：
Taal, Maarten W.
中科院分区：
文献类型：
--
作者：
Fraser, Simon D. S.;Barker, Jenny;Taal, Maarten W.
目的确定在初级保健中轻度至中度慢性肾脏病（CKD）患者的合并症、健康相关生活质量（HRQoL）和功能损害之间的相关性。设计：前瞻性队列研究中5年随访时的横断面分析。设置32全科医生手术在英格兰。参与者1008例CKD 3期受试者（Derby研究肾脏风险基线招募的1741例受试者），他们存活至5年，并具有HRQoL和功能状态（FS）的完整随访数据。主要和次要结局指标HRQoL使用5级EQ-5D版本（EQ-5D-5L，包括活动、自我护理、日常活动、疼痛/不适和焦虑/抑郁领域，指数值使用从英国普通人群计算的效用评分）评估，FS使用Karnofsky体能状态量表（功能损害定义为Karnofksy评分
Objectives To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care. Design Cross-sectional analysis at 5-year follow-up in a prospective cohort study. Setting Thirty-two general practitioner surgeries in England. Participants 1008 participants with CKD stage 3 (of 1741 people recruited at baseline in the Renal Risk in Derby study) who survived to 5 years and had complete follow-up data for HRQoL and functional status (FS). Primary and secondary outcome measures HRQoL assessed using the 5-level EQ-5D version (EQ-5D-5L, with domains of mobility, self-care, usual activities, pain/discomfort and anxiety/depression and index value using utility scores calculated from the English general population), and FS using the Karnofsky Performance Status scale (functional impairment defined as Karnofksy score