The role of the pancreatic endocannabinoid system in glucose metabolism
The role of the pancreatic endocannabinoid system in glucose metabolism
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DOI：
10.1016/j.beem.2008.10.012
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发表时间：
2009-02-01
影响因子：
7.4
通讯作者：
Rodriguez de Fonseca, Fernando
中科院分区：
文献类型：
--
作者：
Bermudez-Silva, Francisco J.;Perez, Juan Suarez;Rodriguez de Fonseca, Fernando
内源性大麻素系统参与能量稳态的调节，这一事实导致了一组新的治疗药物复杂的肥胖症和糖尿病的鉴定。大麻素受体拮抗剂现在在临床实践中成为现实。这种拮抗剂用于减少体重增加、降低胆固醇和改善葡萄糖稳态的用途是基于内源性大麻素通过与中枢和外周靶（包括脂肪组织、肌肉、肝脏和内分泌胰腺）相互作用来协调调节能量稳态的能力。在这篇综述中，我们将分析存在的主要细胞类型的胰岛，以及内源性大麻素和父母acyethanolamides在激素分泌和葡萄糖稳态的生理相关性，该系统。我们还将分析这些发现在临床实践中可能产生的影响，以及调节葡萄糖稳态和胰岛素/胰高血糖素分泌的新治疗策略的潜在结果。(C)2008爱思唯尔有限公司版权所有。
The endogenous cannabinoid system participates in the regulation of energy homeostasis, and this fact led to the identification of a new group of therapeutic agents for complicated obesity and diabetes. Cannabinoid receptor antagonists are now realities in clinical practice. The use Of Such antagonists for reducing body weight gain, lowering cholesterol and improving glucose homeostasis is based on the ability of the endocannabinoids to coordinately regulate energy homeostasis by interacting with central and peripheral targets, including adipose tissue, Muscle, liver and endocrine pancreas. In this review we will analyse the presence of this system in the main cell types of the islets of Langerhans, as well as the physiological relevance of the endocannabinoids and parent acylethanolamides in hormone secretion and glucose homeostasis. We will also analyse the impact that these findings may have in clinical practice and the potential Outcome of new therapeutic strategies for modulating glucose homeostasis and insulin/glucagon secretion. (C) 2008 Elsevier Ltd. All rights reserved.