Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study
Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study
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DOI：
10.1192/bjp.bp.111.098897
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发表时间：
2012-07-01
影响因子：
10.5
通讯作者：
O'Brien, John T.
中科院分区：
文献类型：
--
作者：
Firbank, Michael J.;Teodorczuk, Andrew;O'Brien, John T.
背景脑白质变化（WMC）与抑郁症状相关，但这种关联的方向性仍不清楚。目的调查基线和事件抑郁以及白质变化进展之间的关系。方法 在一项纵向多中心泛欧研究（老年人脑白质疏松和残疾，LADIS）中，64 岁以上的参与者接受了基线磁共振成像 (MRI) 和临床评估。 3 年时进行重复扫描。抑郁结果根据抑郁发作和老年抑郁量表（GDS）进行评估。使用改良的鹿特丹进展量表测量 WMC 的进展。结果 WMC 的进展与研究第 3 年期间的抑郁事件显着相关（P = 0.002），并且在控制残疾转变、基线 WMC 和基线抑郁史后仍然显着。 WMC 进展与 GDS 评分之间没有显着相关性，WMC 进展与基线抑郁史之间也没有显着相关性。结论我们的结果支持血管性抑郁假说，并表明 WMC 是晚年抑郁症发病机制的因果关系。
BackgroundBrain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear.AimsTo investigate the relationship between baseline and incident depression and progression of white matter changes. Method In a longitudinal multicentre pan-European study (Leukoaraiosis and Disability in the elderly, LADIS), participants aged over 64 underwent baseline magnetic resonance imaging (MRI) and clinical assessments. Repeat scans were obtained at 3 years. Depressive outcomes were assessed in terms of depressive episodes and the Geriatric Depression Scale (GDS). Progression of WMC was measured using the modified Rotterdam Progression scale.ResultsProgression of WMC was significantly associated with incident depression during year 3 of the study (P = 0.002) and remained significant after controlling for transition to disability, baseline WMC and baseline history of depression. There was no significant association between progression of WMC and GDS score, and no significant relationship between progression of WMC and history of depression at baseline.ConclusionsOur results support the vascular depression hypothesis and implicate WMC as causal in the pathogenesis of late-life depression.