Avoidance task training potentiates phasic pontine-wave density in the rat: A mechanism for sleep-dependent plasticity
Avoidance task training potentiates phasic pontine-wave density in the rat: A mechanism for sleep-dependent plasticity
复制标题
DOI：
10.1523/jneurosci.20-22-08607.2000
复制
发表时间：
2000-11-15
影响因子：
5.3
通讯作者：
Datta, S
中科院分区：
文献类型：
--
作者：
Datta, S
对人类和动物学习和记忆的行为学研究都支持睡眠在巩固和整合记忆中的作用。本研究通过研究快速眼动(REM)睡眠的状态依赖相体征与学习之间的关系，探讨了睡眠依赖行为可塑性的可能生理机制。在自由活动大鼠进行条件性回避学习或对照学习后，同时记录皮层脑电、肌电、眼球运动、海马theta波和脑桥波(P波)。在学习试验后，与对照试验相比，大鼠的快速眼动睡眠时间增加了25.5%，处于慢波睡眠和快速眼动睡眠过渡状态(ts-R)的时间增加了180.6%。REM睡眠和TS-R行为状态都以P波的存在为特征。在学习阶段后的前四次REM睡眠中，与对照阶段相比，P波密度显著增加。此外，第一次和第三次快速眼动睡眠之间的P波密度变化与初始训练阶段和睡眠后重测阶段之间任务表现的改善成正比。这些结果表明，训练后快速眼动睡眠阶段P波密度的增加与回避任务学习的有效巩固和保持有关。
Behavioral studies of learning and memory in both humans and animals support a role for sleep in the consolidation and integration of memories. The present study explored possible physiological mechanisms of sleep-dependent behavioral plasticity by examining the relationship between learning and state-dependent phasic signs of rapid eye movement (REM) sleep. Cortical electroencephalogram, electromyogram, eye movement, hippocampal theta -wave, and pontine-wave (P-wave) measures were recorded simultaneously in freely moving rats after a session of conditioned avoidance learning or a control session. After learning trials, rats spent 25.5% more time in REM sleep and 180.6% more time in a transitional state between slow-wave sleep and REM sleep (tS-R) compared with that in control trials. Both REM sleep and tS-R behavioral states are characterized by the presence of P-waves. P-wave density was significantly greater in the first four episodes of REM sleep after the learning session compared with the control session. Furthermore, the P-wave density change between the first and third REM sleep episodes was proportional to the improvement of task performance between the initial training session and the postsleep retest session. These findings show that the increase in P-wave density during the post-training REM sleep episodes is correlated with the effective consolidation and retention of avoidance task learning.