Alterations of AQP2 expression in trigeminal ganglia in a murine inflammation model
Alterations of AQP2 expression in trigeminal ganglia in a murine inflammation model
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DOI：
10.1016/j.neulet.2008.11.014
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发表时间：
2009-01-16
影响因子：
2.5
通讯作者：
Rodella, Luigi F.
中科院分区：
文献类型：
--
作者：
Borsani, Elisa;Bernardi, Simona;Rodella, Luigi F.
水通道蛋白 (AQP) 是参与渗透调节的小膜通道蛋白。迄今为止，在神经系统中仅发现了AQP1、AQP2、AQP4和AQP9。一般来说，它们参与神经组织中的水运动，然而，最近的数据表明 AQP 参与神经传递。在这项工作中，我们使用免疫组织化学和免疫印迹分析评估了口周急性炎性疼痛动物模型中小鼠三叉神经节中 AQP1 和 AQP2 的表达。我们的数据首次表明，急性炎性疼痛中三叉神经节中 AQP2 表达的改变表明 AQP2 主要在小尺寸神经元和施万细胞中增加和细胞内重新分布。除此之外，AQP1 表达保持不变。总体而言，这些数据支持 AQP2 参与周围神经系统疼痛传递的假设。 (c) 2008 Elsevier Ireland Ltd. 保留所有权利。
Aquaporins (AQPs) are small membrane channel proteins involved in osmoregulation. To date, only AQP1, AQP2, AQP4 and AQP9 have been found in the nervous system. Generally, they are involved in water movement in nervous tissue, nevertheless, recent data would suggest the involvement of AQPs in neurotransmission. In this work, we have evaluated the expression of AQP1 and AQP2 in the trigeminal ganglia of mice in an animal model of perioral acute inflammatory pain using immunohistochemistry and immunoblotting analysis. Our data have shown for the first time, the alteration of AQP2 expression in trigeminal ganglia in acute inflammatory pain showing increased and intracellular redistribution of AQP2 mainly in small-sized neurons and Schwann cells. Apart from this, the AQP1 expression remained unaltered. On the whole, these data support the hypothesis that AQP2 is involved in pain transmission in the peripheral nervous system. (c) 2008 Elsevier Ireland Ltd. All rights reserved.