Distribution of epithelial-specific antigen in uterine cervix with endocervical glandular dysplasia.
Distribution of epithelial-specific antigen in uterine cervix with endocervical glandular dysplasia.
复制标题
宫颈内膜腺发育不良的子宫颈上皮特异性抗原的分布。
DOI：
10.1006/gyno.1997.4779
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发表时间：
1997
影响因子：
4.7
通讯作者：
H. Kanazaki
中科院分区：
文献类型：
--
作者：
K. Umezaki;M. Sanezumi;H. Okada;A. Okamura;A. Tsubra;H. Kanazaki
宫颈腺癌的自然病程很大程度上未知，宫颈内腺发育不良是否是恶性肿瘤形成的先兆病变是一个有争议的问题。本研究的目的是阐明宫颈管腺体发育不良与子宫宫颈管腺癌的关系。 1984年1月至1992年4月，组织学确诊宫颈腺体异常31例，其中宫颈管腺体发育不良11例，原位腺癌5例，微浸润腺癌4例，浸润性腺癌11例。在这些宫颈管腺体发育不良及相关病变病例中检查了上皮特异性抗原 (ESA) 的免疫组织化学定位，并与 10 个正常宫颈管标本进行了比较。 ESA 免疫反应性通常存在于正常宫颈内膜细胞的基底外侧膜中。然而，随着宫颈内膜细胞的恶变，ESA的表达从基底外侧膜到弥漫性细胞质膜逐渐增加，11例腺体发育不良中有6例，9例原位和微浸润腺癌中有9例，11例浸润性腺癌中有11例。这一发现表明，ESA是宫颈内膜腺体发育不良及相关恶变病变的有用标志物，并提示宫颈内膜腺体发育不良可能是宫颈腺癌的前驱病变。
The natural history of cervical adenocarcinoma is largely unknown, and whether endocervical glandular dysplasia is a precursor lesion to malignant tumor formation is a controversial issue. The aim of this study was to clarify the relationship of endocervical glandular dysplasia to the uterine endocervical adenocarcinoma. Thirty-one cases of glandular abnormalities of the uterine cervix were identified histologically from January 1984 to April 1992. These included 11 cases of endocervical glandular dysplasia, 5 cases of adenocarcinoma in situ, 4 cases of microinvasive adenocarcinoma, and 11 cases of invasive adenocarcinoma. The immunohistochemical localization of epithelial-specific antigen (ESA) was examined in these cases of endocervical glandular dysplasia and related lesions, and was compared to 10 normal endocervical specimens. ESA immunoreactivities were usually present in the basolateral membrane of endocervical cells in the normal endocervix. However, the expressions of ESA were increasing from the basolateral membrane to the diffuse cytoplasmic membrane, along with the malignant transformation of the endocervical cells, in 6 of 11 cases with glandular dysplasia, in 9 of 9 cases with in situ and microinvasive adenocarcinomas, and in 11 of 11 cases with invasive adenocarcinomas. This finding indicates that ESA is a useful marker for endocervical glandular dysplasia and related lesions with malignant transformation, and suggests that endocervical glandular dysplasia may be a precursor lesion to uterine cervical adenocarcinomas.