EPILEPSY WITH ELECTRICAL STATUS EPILEPTICUS DURING SLOW SLEEP AND SECONDARY BILATERAL SYNCHRONY
EPILEPSY WITH ELECTRICAL STATUS EPILEPTICUS DURING SLOW SLEEP AND SECONDARY BILATERAL SYNCHRONY
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DOI：
10.1111/j.1528-1157.1994.tb02561.x
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发表时间：
1994-09-01
期刊：
影响因子：
5.6
通讯作者：
OHTAHARA, S
中科院分区：
文献类型：
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作者：
KOBAYASHI, K;NISHIBAYASHI, N;OHTAHARA, S
对3例“癫痫伴慢波睡眠期癫痫电持续状态”（ESES）患儿，采用二维自回归模型，通过相干分析和相位分析，估计脑电棘波活动的两半球间小时间差（TD），以区分原发性双侧同步和继发性双侧同步慢波睡眠（CSWS）中的连续弥散棘波。在慢波睡眠期间，明显双侧同步棘波爆发（BSSW）发作时的最大TD为12.0-26.5 ms（平均20.3 ms），3例患者的8个爆发中具有一致的主导半球，表明SBS是其CSWS的病理生理学。这一建议得到了他们的临床EEG结果的支持，包括单次口服氯巴占（CLB）对EEG的影响。对2例非典型失神发作的3次发作性BSSW进行了分析，获得了发作时的最大TD为17.9-41.7 ms（平均26.3 ms），与睡眠中相同的主导侧，也表明了SBS。爆发内TD变化的检查显示，在爆发的后半部分，无论是睡眠或发作脑电图的非典型缺席，并建议在ESES的SBS的产生中胼胝体的作用没有一致的消失TD。
In 3 children with ''epilepsy with electrical status epilepticus during slow sleep'' (ESES), we estimated interhemispheric small time differences (TDs) during spike-wave activity in EEG by coherence and phase analysis by the two-dimensional autoregressive model to differentiate their continuous diffuse spike-waves during slow-wave sleep (CSWS) between primary bilateral synchrony and secondary bilateral synchrony (SBS). Maximal TDs at onset of apparently bilateral synchronous spike-wave bursts (BSSWs) during slow-wave sleep were 12.0-26.5 ms (mean 20.3 ms) with consistent leading hemispheres in eight bursts of the 3 patients, indicating SBS as pathophysiology of their CSWS. This suggestion was supported by their clinico-EEG findings, including the effect of a single oral dose of clobazam (CLB) on EEG. Three ictal BSSWs of atypical absence seizures in 2 patients were also analyzed to obtain maximal TDs of 17.9-41.7 ms (mean 26.3 ms) at onset, with the same leading sides as in sleep, also indicating SBS. Examination of intraburst TD variations showed no consistent disappearance of TDs during the latter part of the bursts, in either sleep or the ictal EEGs of atypical absences, and a role of the corpus callosum was suggested in the generation of SBS in ESES.