Keyhole chemical exchange saturation transfer.

Keyhole chemical exchange saturation transfer.
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DOI:
10.1002/mrm.23310
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发表时间:
2012-10
影响因子:
3.3
通讯作者:
Vinogradov E
Vinogradov E
中科院分区:
医学3区
文献类型:
--
作者:
Varma G;Lenkinski RE;Vinogradov E

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锁孔技术,它涉及在低分辨率下的动态数据的采集与高分辨率的参考相结合,开发的化学交换饱和转移(CEST)成像,即锁孔CEST的目的。低分辨率数据是通过在Z-谱的不同频率处施加饱和来采集的,沿着是在没有饱和的情况下拍摄的高分辨率参考图像。三种方法的高分辨率重建的锁孔CEST评价使用的值从定量高分辨率CEST地图。此外,Keyhole CEST用于收集用于B 0校正的数据。使用羟基中的质子交换,评价用于CEST对比生成的Keyhole方法。首先,使用葡萄糖和硫酸软骨素样品在体外评估该技术。接下来,工作在体内扩展,以探索其适用性gagCEST。如果感兴趣的结构或区域不受低分辨率数据集的限制,使用Keyhole CEST可以找到类似的定量gagCEST值。
The keyhole technique, which involves the acquisition of dynamic data at low resolution in combination with a high-resolution reference, is developed for the purposes of chemical exchange saturation transfer (CEST) imaging, i.e. Keyhole CEST. Low-resolution data are acquired with saturation applied at different frequencies for Z-spectra, along with a high-resolution reference image taken without saturation. Three methods for high-resolution reconstruction of Keyhole CEST are evaluated using the values from quantitative high-resolution CEST maps. In addition, Keyhole CEST is applied for collection of data used for B0 correction. The Keyhole approach is evaluated for CEST contrast generation using exchanging protons in hydroxyl groups. First, the techniques are evaluated in vitro using samples of dextrose and chondroitin sulfate. Next, the work is extended in vivo to explore its applicability for gagCEST. Comparable quantitative gagCEST values are found using Keyhole CEST, provided the structure or region of interest is not limited by the low-resolution dataset.
DOI: 10.1002/jmri.1880060512
发表时间: 1996-09-01
期刊: JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子: --
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Chandra, S;Liang, ZP;Lauterbur, PC
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