Responsiveness of the Patient-reported Outcomes Measurement Information System (PROMIS) Pediatric Measures to Changes in Disease Status and Quality of Life Among Children and Adolescents With Crohn's Disease
Responsiveness of the Patient-reported Outcomes Measurement Information System (PROMIS) Pediatric Measures to Changes in Disease Status and Quality of Life Among Children and Adolescents With Crohn's Disease
复制标题
DOI：
10.1093/ibd/izaa083
复制
发表时间：
2021-03-01
影响因子：
4.9
通讯作者：
Kappelman, Michael D.
中科院分区：
文献类型：
--
作者：
Brenner, Erica J.;Long, Millie D.;Kappelman, Michael D.
背景：PROMIS 儿科领域提供慢性病儿童的身体、情感和社会健康的自我报告测量。我们评估了 PROMIS 儿科措施对克罗恩病 (CD) 儿童疾病活动度和疾病特异性、健康相关生活质量 (HRQOL) 变化的反应性。方法：IBD Partners Kids & Teens 是一个基于互联网的炎症性肠病 (IBD) 儿童队列。 9 至 17 岁的参与者报告了与疾病活动（简称克罗恩病活动指数 [sCDAI]）、IMPACT-III HRQOL 测量和 5 个 PROMIS 儿科领域相关的症状。我们使用混合线性模型进行纵向分析，以检查 PROMIS 儿科测量对 sCDAI 和 IMPACT-III 变化的反应程度。结果：我们的研究样本包括 544 名患有 CD 的参与者（平均年龄 13 岁，44% 为女性）。所有 PROMIS 儿科领域都对 sCDAI 的变化做出了反应，表明身体、情绪和社会健康得到改善，这与疾病活动性的改善相对应，反之亦然 (P < 0.001)。观察到的影响估计范围从同伴关系的 1.8 到疲劳的 6.8。在完成 2 份或更多报告的 246 名参与者中，527 名参与者的疾病活动稳定，72 名病情恶化，67 名有所改善。PROMIS 儿科评分的变化与 IMPACT-III 的变化相关（焦虑 r = -0.43，抑郁症状 r = -0.45，疼痛干扰 r = -0.43，疲劳 r = -0.59，同伴 r = 0.23结论：本研究为 PROMIS 儿科测量对儿科 CD 患者疾病状态和 HRQOL 变化的纵向反应性提供了证据。
Background: PROMIS Pediatric domains provide self-reported measures of physical, emotional, and social health in children with chronic conditions. We evaluated the responsiveness of the PROMIS Pediatric measures to changes in disease activity and disease-specific, health-related quality of life (HRQOL) in children with Crohn's disease (CD).Methods: IBD Partners Kids & Teens is an internet-based cohort of children with inflammatory bowel disease (IBD). Participants age 9 to 17 report symptoms related to disease activity (short Crohn's Disease Activity Index [sCDAI]), the IMPACT-III HRQOL measure, and 5 PROMIS Pediatric domains. We conducted longitudinal analyses using mixed linear models to examine the extent to which PROMIS Pediatric measures respond to changes in sCDAI and IMPACT-III.Results: Our study sample included 544 participants with CD (mean age 13 years, 44% female). All PROMIS Pediatric domains responded to changes in sCDAI, indicating improved physical, emotional, and social health, corresponding to improved disease activity and the converse (P < 0.001). Observed effect estimates ranged from 1.8 for peer relationships to 6.8 for fatigue. Of 246 participants with 2 or more completed reports, disease activity was stable in 527, worse in 72, and improved in 67. Changes in PROMIS Pediatric scores were associated with changes in IMPACT-III (r = -0.43 for anxiety, r = -0.45 for depressive symptoms, r = -0.43 for pain interference, r = -0.59 for fatigue, and r = 0.23 for peer relationships).Conclusions: This study provides evidence for the longitudinal responsiveness of the PROMIS Pediatric measures to change in disease status and HRQOL in pediatric CD patients.