Complex evolution of orthologous and paralogous decarboxylase genes.
Complex evolution of orthologous and paralogous decarboxylase genes.
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直系同源和旁系同源脱羧酶基因的复杂进化。
DOI：
10.1046/j.1420-9101.2003.00652.x
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发表时间：
2004
影响因子：
2.1
通讯作者：
Ayala,FJ
中科院分区：
文献类型：
--
作者：
Sáenz-de-Miera,LE;Ayala,FJ
脱羧酶参与动物的神经递质合成和植物的次生代谢途径。不同的脱羧酶蛋白质的特征在于其不同的底物特异性，但由同源基因编码。我们在最大似然框架内研究了动物中多巴胺脱羧酶（Ddc）、组氨酸脱羧酶（Hdc）和α-甲基多巴超敏酶（amd）以及植物中色氨酸脱羧酶（Wdc）和酪氨酸脱羧酶（Ydc）的进化关系。进化速率是异质的。在同一谱系中的旁系同源基因之间存在差异：在Ddcvs中，每个位点每年有4.13×10− 10个核苷酸替换。 1.95 inHdc;在不同谱系中，Ddcvs. 4.13在某些谱系中，Ddc的时间变化很大，在果蝇中，Ddc的时间变化从3.7到54.9不等。我们的结果与分子钟假说不一致。
The decarboxylases are involved in neurotransmitter synthesis in animals, and in pathways of secondary metabolism in plants. Different decarboxylase proteins are characterized for their different substrate specificities, but are encoded by homologous genes. We study, within a maximum‐likelihood framework, the evolutionary relationships amongdopa decarboxylase(Ddc),histidine decarboxylase(Hdc) andα‐methyldopa hypersensitive(amd) in animals, andtryptophan decarboxylase(Wdc) andtyrosine decarboxylase(Ydc) in plants. The evolutionary rates are heterogeneous. There are differences between paralogous genes in the same lineages: 4.13 × 10−10nucleotide substitutions per site per year in mammalianDdcvs. 1.95 inHdc; between orthologous genes in different lineages, 7.62 in dipteranDdcvs. 4.13 in mammalianDdc; and very large temporal variations in some lineages, from 3.7 up to 54.9 in theDrosophila Ddclineage. Our results are inconsistent with the molecular clock hypothesis.