Amphetamine decrease the expression and acquisition of appetitive conditioning but increases the acquisition of anticipatory responding over a trace interval
Amphetamine decrease the expression and acquisition of appetitive conditioning but increases the acquisition of anticipatory responding over a trace interval
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DOI：
10.1177/0269881104047279
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发表时间：
2004-12-01
影响因子：
4.1
通讯作者：
Cassaday, HJ
中科院分区：
文献类型：
--
作者：
Kantini, E;Norman, C;Cassaday, HJ
安非他明对选择性学习的影响进行了测试，在跟踪条件反射程序，其中的信息量的条件刺激（G）（噪音）是通过引入一个时间间隔前的非条件刺激（UCS）（食物）的交付操纵。结果表明，d-苯丙胺（0.5和1.5毫克/公斤）的表达（实验1b）和收购（实验2）的食欲条件反射受损。这是真实的痕迹和连续条件组。0.5 mg/kg剂量的d-苯丙胺的作用不归因于药物的一般运动（CS前测量）或激励（UCS后测量）作用。此外，在无药物消退试验中证实了相同的效应模式（食欲调节受损，无论CS和UCS之间的痕量间隔如何）。与安非他明下观察到的联合学习的获得和表达中的一般抑郁相比，0.5 mg/kg剂量促进了在跟踪间隔后期做出的预期反应的获得（在实验2中，但同样不是实验1b中先前条件反射的表达）。这表明低剂量d-安非他明对学习CS和UCS之间的时间关系有可分离的影响。
The effects of amphetamine on selective learning were tested in a trace conditioning procedure, in which the informativeness of the conditioned stimulus (G) (noise) was manipulated through the introduction of a time interval before the delivery of the unconditioned stimulus (UCS) (food). The results showed that d-amphetamine (0.5 and 1.5 mg/kg) impaired both the expression (Experiment 1b) and acquisition (Experiment 2) of appetitive conditioning. This was true for both trace and contiguously conditioned groups. The effects of the 0.5 mg/kg dose of d-amphetamine were not attributable to general motor (measured pre-CS) or motivational (measured post-UCS) effects of the drug. Moreover, the same pattern of effects (impaired appetitive conditioning, irrespective of the trace interval between CS and UCS) was confirmed in drug-free extinction tests. By contrast to the general depression in the acquisition and expression of associative learning observed under amphetamine, the 0.5 mg/kg dose promoted the acquisition of anticipatory responses made later in the trace interval (in Experiment 2 but, again, not the expression of previous conditioning in Experiment 1b). This suggests a dissociable effect of Low-dose d-amphetamine on learning about the temporal relationship between CS and UCS.