Rearing experience and biogenic amine activity in infant rhesus monkeys
Rearing experience and biogenic amine activity in infant rhesus monkeys
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DOI：
10.1016/0006-3223(95)00663-x
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发表时间：
1996-09-01
影响因子：
10.6
通讯作者：
Kraemer, GW
中科院分区：
文献类型：
--
作者：
Clarke, AS;Hedeker, DR;Kraemer, GW
在这份报告中，我们提出的证据表明，早期的社会经验的影响方面的功能，大脑生物胺系统最显着的去甲肾上腺素能系统。在出生后的前6个月内，在母亲与同伴饲养的猴婴儿中研究了生物胺活性，并响应于两次房屋转换，去甲肾上腺素（NE），3-甲氧基-4-羟基苯乙二醇（MHPG），二羟基苯乙酸（DOPAC），高香草酸（HVA），采用免疫组化法检测脑脊液（CSF）中5-羟吲哚乙酸（5-HLAA）水平。在早期发育过程中，饲养的猴子的CSF中去甲肾上腺素和MHPG水平显著高于母亲饲养的动物，但与母亲饲养的动物相比，对分离和组形成的NE反应减弱。同伴饲养的猴子表现出更大的发展下降5-HIAA水平比母亲饲养的猴子。在早期发育过程中，DOPAC或HVA没有养育效应;然而，同龄饲养的猴子在6-8个月大时显示出显著较低的HVA和DOPAC浓度。结果增加了灵长类母亲对其婴儿中枢神经系统神经递质系统的心理生物学发育的影响的证据，并表明去甲肾上腺素能系统对早期经历更敏感。
In this report we present evidence that early social experience influences aspects of the function of brain biogenic amine systems most notably the noradrenergic system. Biogenic amine activity was studied in mother- vs. peer-reared monkey infants over the first 6 months of life and in response to two housing transitions, Norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ann 5-hydroxyindoleacetic acid (5-HLAA) levels in cerebrospinal fluid (CSF) were measured Peer-reared monkeys showed significantly higher CSF levels of norepinephrine and MHPG than mother-reared animals over early development, but showed an attentuated NE response to separation and group formation compared to mother-reared animals. Peer-reared monkeys showed a greater developmental decline in 5-HIAA levels than mother-reared monkeys. There were no rearing effects for DOPAC or HVA over early development; however, peer-reared monkeys showed significantly lower HVA and DOPAC concentrations at 6-8 months of age, The results add to evidence for the influence of primate mothers on the psychobiological development of central nervous system neurotransmitter systems in their infants, and suggest that the noradrenergic system is among the more sensitive of these to early experience.