Vesicoureteral reflux and the extracellular matrix connection.
Vesicoureteral reflux and the extracellular matrix connection.
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膀胱输尿管反流与细胞外基质连接。
DOI：
10.1007/s00467-016-3386-5
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Gupta,IndraR
中科院分区：
文献类型：
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作者：
Tokhmafshan,Fatima;Brophy,PatrickD;Gbadegesin,RasheedA;Gupta,IndraR
原发性膀胱输尿管反流（VUR）是一种常见的儿童疾病，由于输尿管膀胱交界处的发育缺陷。结缔组织疾病患者的VUR患病率，以及输尿管和膀胱壁肌肉组织在抗反流机制中的重要性，提示输尿管膀胱连接处细胞外基质（ECM）缺陷可能导致VUR。本文将讨论平滑肌及其支持的ECM微环境在VUR中的功能，并探讨VUR与ECM相关基因突变的关系。
Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes.