Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes
Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes
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DOI：
10.3748/wjg.14.2867
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发表时间：
2008-05-14
影响因子：
4.3
通讯作者：
Pourshams, Akram
中科院分区：
文献类型：
--
作者：
Jamali, Raika;Khonsari, Mahmoodreza;Pourshams, Akram
目的：确定的患病率和原因持续升高的丙氨酸氨基转移酶（ALT）水平之间的一般人群在北方Iran.METHODS：共2292（1376女性，年龄18-75岁），选择了系统的整群随机抽样的城市和村庄的贡巴德和Kalaleh在戈莱斯坦省，并邀请参加这项研究。记录了有关饮酒和药物治疗的全面病史。测量体重指数（BMI）、病毒标志物和ALT水平。ALT ≥ 40 U/L者，6个月内复查2次。ALT升高≥ 2倍者视为ALT持续升高。非酒精性脂肪性肝病（NAFLD）的诊断依据是超声检查发现的脂肪肝证据，排除其他病因。结果：共有2049例（1351名女性）患者参加了这项研究，162例（7.9%）在第一次测量时ALT水平升高。64例（3.1%）受试者检测到ALT持续升高，其中51例（79.6%）无明显病因，6例（9.3%）为B型肝炎，4例（6.2%）为丙型肝炎病毒（HCV）感染，3例（4.6%）为酒精性肝炎。NAFLD和酒精性肝炎的患病率分别为2.04%（42例）和0.1%（3例）。NAFLD与男性、超重、糖尿病和居住在城市地区有关[比值比= 3.03（95% CI：1.6-5.72），4.21（95%CI：1.83-9.68），2.86（95%CI：1.05-7.79）和2.04（95%CI：1.00-4.16）]。结论：非酒精性脂肪性肝病是伊朗普通人群中ALT水平持续升高的最常见原因。(C)2008年WJG。All rights reserved.
AIM: To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran.METHODS: A total of 2292 (1376 female, aged 18-75 year), were selected by systematic clustered random sampling from the cities and villages of Gonbad and Kalaleh in Golestan Province and invited to participate in the study. A comprehensive history regarding alcohol drinking and medication was taken. Body mass index (BMI), viral markers and ALT levels were measured. If ALT level was >= 40 U/L, it was rechecked twice within 6 mo. Those with >= 2 times elevation of ALT were considered as having persistently elevated ALT level. Non-alcoholic fatty liver disease (NAFLD) was diagnosed based on evidence of fatty liver upon sonography and excluding other etiology.RESULTS: A total of 2049 (1351 female) patients participated in the study, 162 (7.9%) had elevated ALT level at the first measurement. Persistently elevated ALT level was detected in 64 (3.1%) participants, with 51 (79.6%) with no obvious etiology, six (9.3%) with Hepatitis B, four (6.2%) with Hepatitis C virus (HCV) infection and three (4.6%) with alcoholic hepatitis. The prevalence of NAFLD and alcoholic hepatitis was 2.04% (42 patients) and 0.1% (three), respectively. There was correlation between NAFLD and male gender, overweight, diabetes and living in an urban area [odds ratio = 3.03 (95% CI: 1.6-5.72), 4.21 (95% CI: 1.83-9.68), 2.86 (95% CI: 1.05-7.79) and 2.04 (95% CI: 1.00-4.16) respectively].CONCLUSION: NAFLD is the most common cause of persistently elevated serum ALT level among the general population of Iran. (C) 2008 WJG. All rights reserved.