Limbic encephalitis: A new paraneoplastic auto-immune manifestation associated with metastatic melanoma?
Limbic encephalitis: A new paraneoplastic auto-immune manifestation associated with metastatic melanoma?
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DOI：
10.1016/j.annder.2013.01.424
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发表时间：
2013-04-01
影响因子：
0.9
通讯作者：
Mortier, L.
中科院分区：
文献类型：
--
作者：
Becquart, C.;Ryckewaert, G.;Mortier, L.
背景- 一些研究表明，免疫相关的表现和转移性黑色素瘤的生存期延长之间的关联。在某些癌症的过程中也可观察到由免疫介导的病症驱动的边缘脑炎。- 2009年11月，一名60岁的女性从2005年7月开始随访转移性黑色素瘤，发展为快速进行性认知障碍。临床、生物学、MRI和脑电图异常导致在免疫相关表现的背景下诊断为可能的副肿瘤性边缘叶脑炎，但不能排除化学毒性。自身免疫性甲状腺功能减退症和血小板减少症同时出现。- 据我们所知，这是第一例报告的可能与黑色素瘤相关的副肿瘤性边缘系统脑炎，这是一个与转移性黑色素瘤生存期延长相关的免疫相关疾病的新例子。(C)2013年Elsevier Masson SAS。All rights reserved.
Background. - Several studies indicate an association between immune-related manifestations and prolonged survival in metastatic melanoma. Limbic encephalitis driven by immune-mediated disorders may also be observed during the course of certain cancers.Patients and methods. - In November 2009, a 60-year-old woman followed up for metastatic melanoma since July 2005 developed rapidly progressive cognitive disorder. Clinical, biological, MRI and electroencephalogram abnormalities resulted in diagnosis of probably paraneoplastic limbic encephalitis in a context of immune-related manifestations although chemotoxicity could not be ruled out. Auto-immunity with hypothyroidism and thrombocytopenia were seen concomitantly.Discussion. - To the best of our knowledge, this is the first reported case of probably paraneoplastic limbic encephalitis associated with melanoma, a new example of an immune-related condition associated with prolonged survival in metastatic melanoma. (C) 2013 Elsevier Masson SAS. All rights reserved.