Morphological and membrane characteristics of spider and spindle cells isolated from rabbit sinus node.
Morphological and membrane characteristics of spider and spindle cells isolated from rabbit sinus node.
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兔窦房结蜘蛛细胞和梭形细胞的形态和膜特征。
DOI：
10.1152/ajpheart.2001.280.3.h1232
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Boineau,JP
中科院分区：
文献类型：
--
作者：
Wu,J;Schuessler,RB;Rodefeld,MD;Saffitz,JE;Boineau,JP
This study reports the comparative quantitative, morphological, and electrophysiological properties of two pacemaker cell types, spider and spindle-shaped cells, isolated from the rabbit sinoatrial node. Isolated nodal cells were studied with perforated and ruptured patch whole cell recording techniques. The basic spontaneous cycle length of the spider cells was 381 ± 12 ms, and the basic spontaneous cycle length of the spindle cells was 456 ± 17 ms (n= 12,P< 0.05). The spider cells had a more positive maximum diastolic potential (−54 ± 1 mV) compared with the spindle cells (−68 ± 1mV,P< 0.05). The overshoot and action potential amplitudes were also smaller in the spider cells. The hyperpolarization-activated inward (If) current density, measured from their tail currents, was 15 ± 1.3 pA/pF for the spider cells and 9 ± 0.7 pA/pF for the spindle cells (P< 0.01).Ifcurrent activation voltage was more positive in the spider cells than the spindle cells. Isoproterenol (1 μM) decreased the spontaneous cycle length of the spider cells by 28 ± 3% and the spindle cells by 20 ± 1.5% (P< 0.05). Acetylcholine (0.5 μM) hyperpolarized the membrane potential of the spider cells to −86 ± 0.7mV and the spindle cells to −76 ± 0.8 mV (P< 0.05). In summary, there are at least two distinct pacemaker cell types in the sinus node with different electrophysiological characteristics.
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棕榈酰肉碱改变钠电流并在心室肌细胞中诱导瞬时内向电流。
DOI：
10.1152/ajpheart.1994.266.3.h1034
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Wu,J;Corr,PB
通讯作者：
Corr,PB
影响因子：
5.5
作者：
DENYER, JC;BROWN, HF
通讯作者：
BROWN, HF
A.M.Frace：“通过外部阴离子控制兔窦房结细胞中的超极化激活的阳离子电流。”
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--
脊椎动物心脏主要部分之间肌肉连接的形式和性质。
DOI：
--
发表时间：
--
期刊：
Journal of anatomy and physiology
影响因子：
--
作者：
Arthur Keith;Martin W. Flack
通讯作者：
Martin W. Flack
影响因子：
20.1
作者：
Kwong, KF;Schuessler, RB;Saffitz, JE
通讯作者：
Saffitz, JE