Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review-CORRIGENDUM.
Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review-CORRIGENDUM.
复制标题
DOI：
10.1017/s000711452200109x
复制
发表时间：
2022-12-28
影响因子：
3.6
通讯作者：
Lovegrove, Julie A.
中科院分区：
文献类型：
--
作者：
Sellem, Laury;Jackson, Kim G.;Paper, Laura;Givens, Ian D.;Lovegrove, Julie A.
在流行病学研究中，乳制品消费与某些心脏代谢疾病（CMD）的影响最小或风险降低有关。然而，目前的饮食评估方法不能提供客观和准确的食物摄入量测量。因此，确定乳制品摄入的有效和可靠的生物标志物是最好地确定乳制品消费与健康状况之间关系的重要挑战。本文综述了奇链、反式和支链脂肪酸（FA）等潜在的乳制品脂肪消费生物标志物，这些生物标志物可能会改善对全脂乳制品消费的评估。总的来说，目前使用血清/血浆FA作为乳脂肪消耗的生物标志物主要是基于观察证据，缺乏良好控制的剂量反应干预研究来准确评估这种关系的强度。在前瞻性队列研究中，循环奇数链SFA和反式棕榈油酸与CMD风险的关系研究越来越多，并且似乎始终与2型糖尿病风险降低相关。然而，与心血管疾病的关系尚不清楚。总的来说，在现有证据的基础上增加研究较少的FA，如苗酸和植酸，可能会提供更完整的乳脂肪摄入量评估，并最大限度地减少内源性合成的潜在混淆。最后，目前关于乳制品脂肪酸对已建立的CMD风险生物标志物（如空腹脂质谱和血糖控制标志物）的直接影响的证据主要来自横断面、动物和体外研究，应通过控制良好的人为干预研究来加强。
In epidemiological studies, dairy food consumption has been associated with minimal effect or decreased risk of some cardiometabolic diseases (CMD). However, current methods of dietary assessment do not provide objective and accurate measures of food intakes. Thus, the identification of valid and reliable biomarkers of dairy product intake is an important challenge to best determine the relationship between dairy consumption and health status. This review investigated potential biomarkers of dairy fat consumption, such as odd-chain, trans- and branched-chain fatty acids (FA), which may improve the assessment of full-fat dairy product consumption. Overall, the current use of serum/plasma FA as biomarkers of dairy fat consumption is mostly based on observational evidence, with a lack of well-controlled, dose–response intervention studies to accurately assess the strength of the relationship. Circulating odd-chain SFA and trans-palmitoleic acid are increasingly studied in relation to CMD risk and seem to be consistently associated with a reduced risk of type 2 diabetes in prospective cohort studies. However, associations with CVD are less clear. Overall, adding less studied FA such as vaccenic and phytanic acids to the current available evidence may provide a more complete assessment of dairy fat intake and minimise potential confounding from endogenous synthesis. Finally, the current evidence base on the direct effect of dairy fatty acids on established biomarkers of CMD risk (e.g. fasting lipid profiles and markers of glycaemic control) mostly derives from cross-sectional, animal and in vitro studies and should be strengthened by well-controlled human intervention studies.