Long-term health impacts of hematopoietic stem cell transplantation inform recommendations for follow-up.
Long-term health impacts of hematopoietic stem cell transplantation inform recommendations for follow-up.
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DOI：
10.1586/ehm.11.39
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发表时间：
2011-08
影响因子：
2.8
通讯作者：
Bhatia S
中科院分区：
文献类型：
--
作者：
Bhatia S
移植技术和支持性护理策略的进步使接受治疗的患者的生存率显着提高。然而，造血干细胞移植（HSCT）幸存者面临出现长期并发症的风险，例如内分泌疾病、肌肉骨骼疾病、心肺功能受损和随后的恶性肿瘤。这些并发症对 HSCT 幸存者的发病率和死亡率有直接影响。三分之二的 HSCT 幸存者患有至少一种慢性健康状况；而五分之一的人病情严重或危及生命。移植后存活至少 5 年的 HSCT 患者在 HSCT 后长达 30 年的晚期死亡风险增加四到九倍，预计预期寿命比普通人群低 30%。 HSCT 幸存者所经历的高发病率使得对 HSCT 后并发症高风险的 HSCT 幸存者进行标准化随访至关重要。国际血液和骨髓移植研究中心/欧洲血液和骨髓移植组织/美国血液和骨髓移植协会以及儿童肿瘤学组织长期随访指南提供了此类标准化护理。未来的步骤包括更广泛地传播和完善这些指南。
Advances in transplantation techniques and supportive care strategies have resulted in a significant improvement in survival of those who have undergone treatment. However, hematopoietic stem cell transplantation (HSCT) survivors are at risk of developing long-term complications, such as endocrinopathies, musculoskeletal disorders, cardiopulmonary compromise and subsequent malignancies. These complications have a direct impact on the morbidity and mortality experienced by HSCT survivors. Two-thirds of HSCT survivors develop at least one chronic health condition; while a fifth develop severe or life-threatening conditions. HSCT patients who have survived for at least 5 years post-transplantation are at a fourfold to ninefold increased risk of late mortality for as long as 30 years from HSCT, producing an estimated 30% lower life expectancy compared with the general population. The high burden of morbidity experienced by HSCT survivors makes it critically important that there is standardized follow-up of HSCT survivors at high risk for post-HSCT complications. The Center for International Blood and Marrow Transplant Research/European Group for Blood and Marrow Transplantation/American Society for Blood and Marrow Transplantation and the Children’s Oncology Group long-term follow-up guidelines offer such standardized care. Future steps include wider dissemination and refinement of these guidelines.
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影响因子：
6.2
作者：
Campbell, Stephanie;Sun, Can-Lan;Kurian, Seira;Francisco, Liton;Carter, Andrea;Kulkarni, Sameer;Parker, Pablo;Karanes, Chatchada;Forman, Stephen J.;Bhatia, Smita
通讯作者：
Bhatia, Smita
影响因子：
4.8
作者：
Annaloro, C.;Usardi, P.;Deliliers, G. Lambertenghi
通讯作者：
Deliliers, G. Lambertenghi
影响因子：
6.2
作者：
Choi, Michael;Sun, Can-Lan;Kurian, Seira;Carter, Andrea;Francisco, Liton;Forman, Stephen J.;Bhatia, Smita
通讯作者：
Bhatia, Smita
影响因子：
45.3
作者：
Cohen, Amnon;Rovelli, Attilio;Socie, Gerard
通讯作者：
Socie, Gerard
影响因子：
6.5
作者：
ATKINSON, K;BIGGS, JC;NAIDOO, D
通讯作者：
NAIDOO, D