Lipid metabolism in cancer progression and therapeutic strategies.
Lipid metabolism in cancer progression and therapeutic strategies.
复制标题
癌症进展中的脂质代谢和治疗策略
作者：
Fu Y;Zou T;Shen X;Nelson PJ;Li J;Wu C;Yang J;Zheng Y;Bruns C;Zhao Y;Qin L;Dong Q
摘要脂质代谢异常是癌症中重要的代谢改变。脂肪酸、胆固醇和磷脂是三种最常见的脂质，它们作为能量生产者、信号分子和细胞膜生物合成的源材料。脂质的合成、储存和摄取增强有助于癌症进展。癌症中脂质代谢的重新布线与致癌信号通路的激活和与肿瘤微环境的串扰有关。所产生的活性有利于肿瘤细胞在肿瘤内的恶劣条件下的存活和增殖。脂质代谢也通过影响肿瘤微环境中非癌细胞的功能，特别是免疫相关细胞，在肿瘤免疫原性中发挥重要作用。靶向改变的脂质代谢途径已显示出作为有前景的抗癌疗法的潜力。在这里，我们回顾了最近的证据表明，癌症中的脂质代谢重编程对癌症进展的贡献，并讨论了癌症中脂质代谢重布线的分子机制，以及针对癌症中脂质代谢的潜在治疗策略。这篇综述为充分理解脂质代谢重编程在癌症中的作用提供了新的思路，并为靶向脂质代谢的癌症治疗策略提供了有价值的线索。
Abstract Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signaling molecules, and source material for the biogenesis of cell membranes. The enhanced synthesis, storage, and uptake of lipids contribute to cancer progression. The rewiring of lipid metabolism in cancer has been linked to the activation of oncogenic signaling pathways and cross talk with the tumor microenvironment. The resulting activity favors the survival and proliferation of tumor cells in the harsh conditions within the tumor. Lipid metabolism also plays a vital role in tumor immunogenicity via effects on the function of the noncancer cells within the tumor microenvironment, especially immune‐associated cells. Targeting altered lipid metabolism pathways has shown potential as a promising anticancer therapy. Here, we review recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression, and discuss the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer. This review sheds new light to fully understanding of the role of lipid metabolic reprogramming in the context of cancer and provides valuable clues on therapeutic strategies targeting lipid metabolism in cancer.
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影响因子：
19
作者：
Ackerman, Daniel;Simon, M. Celeste
通讯作者：
Simon, M. Celeste
DOI：
10.1158/1078-0432.ccr-16-2363
发表时间：
2017-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Britten CD;Garrett-Mayer E;Chin SH;Shirai K;Ogretmen B;Bentz TA;Brisendine A;Anderton K;Cusack SL;Maines LW;Zhuang Y;Smith CD;Thomas MB
通讯作者：
Thomas MB
DOI：
10.1073/pnas.1115484108
发表时间：
2011-12-06
影响因子：
11.1
作者：
Barcelo-Coblijn, Gwendolyn;Laura Martin, Maria;Escriba, Pablo V.
通讯作者：
Escriba, Pablo V.
DOI：
10.1038/nrd.2016.252
发表时间：
2017-05
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Brown HA;Thomas PG;Lindsley CW
通讯作者：
Lindsley CW
影响因子：
13.5
作者：
Beyoglu, Diren;Imbeaud, Sandrine;Maurhofer, Olivier;Bioulac-Sage, Paulette;Zucman-Rossi, Jessica;Dufour, Jean-Francois;Idle, Jeffrey R.
通讯作者：
Idle, Jeffrey R.