Whey protein hydrolysates alleviated weight gain and improved muscle in middle-aged obese mice induced by a high-fat diet
Whey protein hydrolysates alleviated weight gain and improved muscle in middle-aged obese mice induced by a high-fat diet
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DOI：
10.1016/j.jff.2022.105241
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发表时间：
2022-10
影响因子：
5.6
通讯作者：
Chenjie Ling;Xiao-fang Chen;Jia-Ying Xu;Guichan Wang;Yan Wang;Yue Sun;Yunfei Li;Z. Wan;X. Tong;K. Hidayat;Wanzhan Zhu;L. Qin;Jing Yang
中科院分区：
文献类型：
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作者：
Chenjie Ling;Xiao-fang Chen;Jia-Ying Xu;Guichan Wang;Yan Wang;Yue Sun;Yunfei Li;Z. Wan;X. Tong;K. Hidayat;Wanzhan Zhu;L. Qin;Jing Yang
乳清蛋白（WP）和乳清蛋白水解物（WPH）可能具有促进体重减轻、保持肌肉和改善肠道微生物群组成的功效。本研究探讨了WPH与WP对肥胖中年小鼠体重管理的影响，包括脂肪量、肌肉量和肠道微生物群组成的变化。本研究结果表明，WPH显著减少能量摄入，减轻体重增加，改善血脂和血糖。此外，WPH减少了异位脂肪沉积，增强了肌肉的抗氧化能力，但对肌肉质量没有显著影响。WPH未能逆转高脂肪饮食导致的微生物多样性减少，但增加了akkermansia和clostridium xviii丰度，降低了alistipous丰度。综上所述，WPH在中年人体重管理中具有良好的应用前景。
Whey protein (WP) and whey protein hydrolysates (WPH) may have the potency to promote weight loss, preserve muscle and improve gut microbiota composition. The present study explored the effect of WPH vs WP on weight management in obese middle-aged mice in the content of changes in fat mass, muscle mass and gut microbiota composition. The present results showed that WPH significantly reduced energy intake, attenuated weight gain and improved blood lipids and glucose. Moreover, WPH reduced ectopic fat deposition and enhanced antioxidant capacity in muscle, but did not significantly affect muscle mass. WPH failed to reverse the microbial diversity reduction caused by a high-fat diet, but increasedAkkermansiaandClostridium XVIIIabundances and decreasedAlistipesabundance. In conclusion, WPH is expected to have good prospects in weight management in middle age.