Body mass index, estimated glucose disposal rate and vascular complications in type 1 diabetes: Beyond glycated haemoglobin
Body mass index, estimated glucose disposal rate and vascular complications in type 1 diabetes: Beyond glycated haemoglobin
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DOI：
10.1111/dme.14529
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发表时间：
2021-02-19
影响因子：
3.5
通讯作者：
Ajjan, Ramzi A.
中科院分区：
文献类型：
--
作者：
Helliwell, Rebecca;Warnes, Harriet;Ajjan, Ramzi A.
目的了解胰岛素抵抗（IR）之间的关系，评估为估计葡萄糖处置率（eGDR），和微血管/大血管并发症的人与1型diabetes.Materials和方法确诊为1型糖尿病的个人被列入本横断面研究。BMI分为正常体重组（18.0-24.9 kg m（-2））、超重组（25.0-29.9 kg m（-2））和肥胖组（>= 30.0 kg m（-2））。我们将eGDR分为四组：eGDR >8、6-7.9、4-5.9和= 8 mg kg（-1）min（-1）和= 8 mg kg（-1）min（-1））的并发症发生率最低，与HbA 1c水平无关。结论肥胖在1型糖尿病中普遍存在，糖尿病并发症不仅与血糖控制有关。IR（评估为eGDR）与微血管和大血管并发症密切相关，与HbA（1c）水平无关。
Aims To understand the relationship between insulin resistance (IR), assessed as estimated glucose disposal rate (eGDR), and microvascular/macrovascular complications in people with type 1 diabetes.Materials and methods Individuals with a confirmed diagnosis of type 1 diabetes were included in this cross-sectional study. BMI was categorised into normal weight (18.0-24.9 kg m(-2)), overweight (25.0-29.9 kg m(-2)) and obese groups (>= 30.0 kg m(-2)). We categorised eGDR into four groups: eGDR >8, 6-7.9, 4-5.9 and = 8 mg kg(-1) min(-1) and = 8 mg kg(-1) min(-1)) had the lowest complication rates irrespective of HbA(1c) levels.Conclusions Obesity is prevalent in type 1 diabetes and diabetes complications are not only related to glucose control. IR, assessed as eGDR, is strongly associated with both microvascular and macrovascular complications, regardless of HbA(1c) levels.