Inducible nitric oxide synthase does not affect resolution of murine chlamydial genital tract infections or eradication of chlamydiae in primary murine cell culture.
Inducible nitric oxide synthase does not affect resolution of murine chlamydial genital tract infections or eradication of chlamydiae in primary murine cell culture.
复制标题
诱导型一氧化氮合酶不影响小鼠衣原体生殖道感染的解决或原代小鼠细胞培养物中衣原体的根除。
DOI：
10.1128/iai.66.2.835-838.1998
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发表时间：
1998
影响因子：
3.1
通讯作者：
Byrne,GI
中科院分区：
文献类型：
--
作者：
Ramsey,KH;Miranpuri,GS;Poulsen,CE;Marthakis,NB;Braune,LM;Byrne,GI
缺乏诱导型一氧化氮合酶（iNOS）或用iNOS抑制剂治疗的小鼠解决了衣原体生殖道感染。此外，用γ干扰素处理原代小鼠细胞培养物在缺乏一氧化氮的情况下限制了衣原体的生长。从这些结果来看，iNOS活性对于解决小鼠衣原体生殖道感染和抑制培养衣原体生长是不必要的。
Mice lacking inducible nitric oxide synthase (iNOS) or treated with iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma interferon restricted chlamydial growth in the absence of nitric oxide. From these results, iNOS activity is unnecessary for the resolution of chlamydial genital tract infections in mice and inhibition of chlamydial growth in culture.