Immunoadjuvant effects of periodontitis-associated bacteria.
Immunoadjuvant effects of periodontitis-associated bacteria.
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牙周炎相关细菌的免疫佐剂作用。
DOI：
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发表时间：
1989
影响因子：
3.5
通讯作者：
T. Ikeda
中科院分区：
文献类型：
--
作者：
K. Ochiai;T. Kurita;K. Nishimura;T. Ikeda
本文研究了牙周致病菌声波提取物（SE）对免疫反应的影响及其佐剂作用。从A. actinomycetemcomitans、伴放线菌B. intermedius和B.在使用C3 H/HeN小鼠的体内实验中，发现牙龈炎菌对抗原本身以及绵羊红细胞（SRBC）具有强的免疫调节活性。在低浓度下，所有SE均能增强小鼠对抗原和SRBC的免疫应答。高浓度的A.放线菌共生菌和B.但不是B的中间体。牙龈炎此外，这些免疫抑制作用增强的3天前注射到SRBC，即使在低浓度，包括B。牙龈炎A.放线菌共生体的依赖于蛋白质部分测试的SE，因为抑制抗SRBC免疫反应恢复链霉蛋白酶处理或加热。在使用中间拟杆菌的类似实验中发现，免疫应答未能恢复，表明其抑制作用是由于热稳定和链霉蛋白酶抗性物质。这些发现，沿着本文提供的数据，支持了这样的假设，即携带这些细菌的患者不仅会受到最初牙周病细菌的全身免疫抑制，而且还会受到继发感染细菌的全身免疫抑制。这些抑制作用还可能增强牙龈缝隙中其他机会生物的致病性。
Sonic extract (SE) from periodontopathic bacteria were studied for their effects on the immune response and adjuvanticity. The preparations of SE from A. actinomycetemcomitans, B. intermedius and B. gingivalis were found to have strong immunomodulating activity against the antigen itself and also sheep erythrocytes (SRBC) in in vivo experiments using C3H/HeN mice. All the SE enhanced the immune response to antigen and SRBC at low concentration. A strong immuno suppressive effect, however, was found at high concentrations of A. actinomycetemcomitans and B. intermedius but not of B. gingivalis. Moreover, these immunosuppressive effects were enhanced by the 3-day-prior injection to SRBC even at low concentrations, including that of B. gingivalis. The suppressive effect of SE from A. actinomycetemcomitans was dependent on the protein fraction in the SE tested, because suppressed anti-SRBC immune response was restored by pronase treatment or heating. Failure to recover immune response, found in a similar experiment using Bacteroides intermedius, indicated that its suppressive effect was due to a heat-stable and pronase-resistant substance. These findings, along with the data presented in this paper, support the hypothesis that patients who harbor these bacteria could suffer systemic immune suppression not only from the initial periodontopathic bacteria but also from secondary infecting bacteria. These suppressive effects may also enhance the pathogenicity of other opportunistic organisms in the gingival crevice.
由伴放线放线杆菌诱导的免疫抑制。
DOI：
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发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Shenker,BJ;McArthur,WP;Tsai,CC
通讯作者：
Tsai,CC
龈沟液针对口腔微生物的抗体。
影响因子：
3.5
作者：
Ebersole,JL;Taubman,MA;Smith,DJ
通讯作者：
Smith,DJ
白色念珠菌诱导抑制的细胞性质研究。
DOI：
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发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Rivas,V;Rogers,TJ
通讯作者：
Rogers,TJ