INCREASED RISK OF LYMPHOMA IN SICCA SYNDROME
INCREASED RISK OF LYMPHOMA IN SICCA SYNDROME
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DOI：
10.7326/0003-4819-89-6-888
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发表时间：
1978-01-01
影响因子：
39.2
通讯作者：
CHUSED, TM
中科院分区：
文献类型：
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作者：
KASSAN, SS;THOMAS, TL;CHUSED, TM
美国国立卫生研究院(NIH)对136名患有西卡综合征的女性进行了癌症风险调查。7例患者从6mo开始发生非霍奇金S淋巴瘤。到他们第一次进入NIH后的13岁。这是同一年龄段普通人群中癌症发病率预期的43.8倍(P<；0.01)。此外，本组还发生了3例沃尔登斯特龙S巨球蛋白血症。8名患者患上了淋巴瘤以外的其他癌症，与根据普通人群普遍存在的发病率所预期的数字相似。有腮腺肿大、脾肿大和淋巴结病病史的患者患淋巴瘤的风险增加。这些临床症状似乎不是未诊断的淋巴瘤的早期表现，而是似乎确定了一组具有显著淋巴反应的西卡综合征患者，他们随后发展为淋巴瘤的风险特别高。
The risk of cancer was ascertained in 136 women with Sicca syndrome followed at the National Institutes of Health (NIH). Seven patients developed non-Hodgkin''s lymphoma from 6 mo. to 13 yr after their first admission to NIH. This was 43.8 times (P < 0.01) the incidence expected from the rates of cancer prevailing among women of the same age range in the general population during this time. In addition, 3 cases of Waldenstrom''s macroglobulinemia occurred in this study group. Eight patients developed cancers other than lymphoma, similar to the number expected based on the rates prevailing in the general population. Patients with a history of parotid enlargement, splenomegaly and lymphadenopathy had an increased risk of lymphoma. These clinical conditions did not appear to be early manifestations of undiagnosed lymphoma but rather seemed to identify a subgroup of patients with Sicca syndrome with marked lymphoid reactivity, who had a particularly high risk of subsequently developing lymphoma.