A new animal model of femoral head osteonecrosis: one that progresses to human-like mechanical failure
A new animal model of femoral head osteonecrosis: one that progresses to human-like mechanical failure
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DOI：
10.1016/s0736-0266(01)00108-5
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发表时间：
2002-03-01
影响因子：
2.8
通讯作者：
Robinson, RA
中科院分区：
文献类型：
--
作者：
Conzemius, MG;Brown, TD;Robinson, RA
现有的股骨头坏死动物模型虽然与人类疾病的早期组织病理学特征表现出不同程度的一致性，但通常不能发展为终末期机械崩溃。本文介绍了一种新的骨坏死动物模型——鸸鹋（Dromaius novaehollandie）。与四足动物相比，这些动物的两足行走和高活动水平对髋关节的生物力学环境更具挑战性。股骨头坏死通过手术诱导，采用缺血（血管结扎）和低温（液氮）损伤相结合的方法。在19只鸸鹋中，有18只鸸鹋在手术损伤后11.75周的平均时间点发展为骨骼结构破坏，其中16只鸸鹋发展为残疾跛行。在组织学上，这些动物表现出与人类早期和晚期病理的密切一致，在6个病例中甚至出现了新月征。由于其巨大的物理尺寸和不断发展为机械塌陷，鸸鹋似乎为接近人类的手术干预研究提供了一个独特的机会，以预防股骨头塌陷。为此，概述了模型细化的各种方向。(C) 2002骨科研究学会。Elsevier Science Ltd.出版。版权所有。
Existing animal models of femoral head osteonecrosis, while displaying varying levels of concordance with early histopathologic features of the human disorder, generally fail to progress to end-stage mechanical collapse. A new animal model of osteonecrosis is here introduced, utilizing the emu (Dromaius novaehollandie). These animals' bipedality and their high activity level represent a much more challenging biomechanical environment to the hip than seen in quadrupedal models of this disorder. Femoral head osteonecrosis was induced surgically, using a combination of ischemic (vessel ligation) and cryogenic (liquid nitrogen) insults. Of nineteen emus allowed free-roaming pen activity to study the natural history of such lesions, eighteen progressed to an osseous structural failure, sixteen of them developing incapacitating lameness at an average time point 11.75 weeks after the surgical insult. Histologically, the animals showed close concordance with both the early- and late-stage human pathology, in six cases even to the point of developing a crescent sign. Because of its large physical size and its consistent progression to mechanical collapse, the emu appears to offer a unique opportunity for the near-human-scale study of surgical interventions to forestall femoral head collapse. Toward this end, various directions for model refinement are outlined. (C) 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.