Tending a complex microbiota requires major immune complexity.
Tending a complex microbiota requires major immune complexity.
复制标题
照顾复杂的微生物群需要高度的免疫复杂性。
DOI：
10.1111/mec.12895
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发表时间：
2014
影响因子：
4.9
通讯作者：
Milligan-Myhre,Kathryn
中科院分区：
文献类型：
--
作者：
Stagaman,Keaton;Guillemin,Karen;Milligan-Myhre,Kathryn
动物在肠道中维持着复杂的微生物群落，这些微生物群落在宿主的健康和发育中扮演着重要的角色。宿主的遗传背景在多大程度上影响其肠道微生物群落的建立和维持仍然是一个悬而未决的问题。我们从对老鼠和人类的研究中知道，外部因素，如饮食和微生物的环境来源，以及宿主免疫因素，在塑造微生物群落方面发挥着重要作用(Costelloet等人)。)。在本期《分子生态学》中，Bolniket等人。(2014A)从从一个湖泊分离的150个遗传多样性的刺鱼中提取肠道微生物群落样本，以提供证据表明适应性免疫反应的另一部分-抗原呈递细胞的主要组织相容性复合体II(MHCII)受体可能在塑造三刺鱼(Gastersteus aculeatus(BolNicket Al))的肠道微生物区系中发挥作用。2014A)。博尔尼基特等人。(2014a)提供了对刺鱼MHCII等位基因及其肠道微生物群落多样性的自然、个体间差异的洞察，并将MHCII受体等位基因多样性的变化与微生物区系的变化联系起来。
Animals maintain complex microbial communities within their guts that fill important roles in the health and development of the host. To what degree a host's genetic background influences the establishment and maintenance of its gut microbial communities is still an open question. We know from studies in mice and humans that external factors, such as diet and environmental sources of microbes, and host immune factors play an important role in shaping the microbial communities (Costelloet al. ). In this issue ofMolecular Ecology, Bolnicket al. (2014a) sample the gut microbial community from 150 genetically diverse stickleback isolated from a single lake to provide evidence that another part of the adaptive immune response, the major histocompatibility complex class II (MHCII) receptors of antigen‐presenting cells, may play a role in shaping the gut microbiota of the threespine stickleback,Gasterosteus aculeatus(Bolnicket al. 2014a). Bolnicket al. (2014a) provide insight into natural, interindividual variation in the diversity of both stickleback MHCII alleles and their gut microbial communities and correlate changes in the diversity of MHCII receptor alleles with changes in the microbiota.