Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy
Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy
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DOI：
10.2169/internalmedicine.2533-18
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发表时间：
2019-01-01
影响因子：
1.2
通讯作者：
Kirito, Keita
中科院分区：
文献类型：
--
作者：
Kawashima, Ichiro;Fukasawa, Hiroko;Kirito, Keita
癌细胞转移到骨髓是相对罕见的，尽管是实体瘤患者骨髓抑制的最重要原因之一。通过活检进行骨髓检查是诊断癌细胞侵入骨髓的标准方法。然而，有时区分神经内分泌癌细胞和造血细胞是具有挑战性的，因为它们的小而圆的形状和类似于血液恶性肿瘤的染色体异常。我们在此报告一个子宫内膜小细胞神经内分泌癌骨髓侵犯的病例，类似治疗相关的骨髓恶性肿瘤。
Metastasis of cancer cells to the bone marrow is relatively rare, despite being one of the most important causes of myelosuppression in patients with solid tumours. A bone marrow examination via a biopsy is the standard method of diagnosing cancer cell invasion into the bone marrow. However, it is sometimes challenging to distinguish neuroendocrine carcinoma cells from haematopoietic cells due to their small, round shape and chromosomal abnormalities resembling haematological malignancies. We herein report a case of bone marrow invasion of small cell neuroendocrine carcinoma of the endometrium mimicking therapy-related myeloid malignancy.