A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm
A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm
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DOI：
10.1161/circgenetics.113.000165
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发表时间：
2013-10-01
影响因子：
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通讯作者：
Bown, Matthew J.
中科院分区：
文献类型：
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作者：
Bradley, Declan T.;Hughes, Anne E.;Bown, Matthew J.
腹主动脉瘤（AAA）是老年人常见的心血管疾病，具有明显的遗传性。与类似的复杂疾病相比，AAA的遗传关联相对较少。我们重新分析了我们的全基因组研究，并在较低的显着性水平上进行了复制暗示性发现关联。方法和结果使用来自英国、新西兰、和澳大利亚的肾下主动脉直径30 mm或AAA破裂患者，以及来自1958年出生队列和国家血液服务队列的5435名未筛选对照者。威康信托个案控制财团。与P的八种暗示性关联
Background Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance.Methods and Results A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter 30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P