Transcallosal motor pathway from affected motor cortex to affected hand in a patient with corona radiata infarct A diffusion tensor tractography and transcranial magnetic stimulation study
Transcallosal motor pathway from affected motor cortex to affected hand in a patient with corona radiata infarct A diffusion tensor tractography and transcranial magnetic stimulation study
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DOI：
10.3969/j.issn.1673-5374.2010.14.015
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发表时间：
2010-07-30
影响因子：
6.1
通讯作者：
Jang, Sung Ho
中科院分区：
文献类型：
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作者：
Jang, Sung Ho
通过经胼胝体途径的运动恢复机制仍然知之甚少。本研究报告了一名患有放射冠梗死的偏瘫患者;它试图使用扩散张量纤维束成像和经颅磁刺激来确认通过经胼胝体运动通路（从受影响的运动皮质到受影响的手）的运动恢复。一名54岁的男性患者和8名年龄匹配的正常受试者入组本研究。患者的右手最初完全瘫痪，但在6个月内缓慢恢复。在对照受试者和患者未受影响的半球（右侧）中，皮质脊髓束起源于运动皮质，并沿着已知的皮质脊髓束通路下行。然而，受累半球的皮质脊髓束在上脑桥被破坏。经颅刺激受影响的（左）运动皮层，运动诱发电位从受影响的（右）拇短展肌表现出较长的潜伏期比相反的运动诱发电位。本研究的结果表明，运动功能的受影响的（右）手恢复通过经胼胝体运动通路从受影响的（左）运动皮层在这个病人。
The mechanisms of motor recovery through the transcallosal pathway remain poorly understood. The present study reports on a hemiplegic patient with corona radiata infarct; it attempts to confirm motor recovery through the transcallosal motor pathway, from the affected motor cortex to the affected hand, using diffusion tensor tractography and transcranial magnetic stimulation. A 54-year-old, male patient and eight age-matched, normal subjects were enrolled in the study. The patient's right hand was initially completely paralyzed, but slowly recovered over 6 months. In the control subjects and the unaffected hemisphere (right) of the patient, the corticospinal tracts originated from the motor cortex and descended along the known corticospinal tract pathway. However, the corticospinal tract of the affected hemisphere was disrupted at the upper pons. Following transcranial stimulation of the affected (left) motor cortex, motor evoked potential from the affected (right) abductor pollicis brevis muscle exhibited longer latency than opposite motor evoked potential. Results from the present study suggest that motor function of the affected (right) hand recovered via the transcallosal motor pathway from the affected (left) motor cortex in this patient.