Pulmonary function is associated with distal aortic calcium, not proximal aortic distensibility. MESA lung study.
Pulmonary function is associated with distal aortic calcium, not proximal aortic distensibility. MESA lung study.
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DOI：
10.3109/15412555.2011.558543
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发表时间：
2011-04
期刊：
影响因子：
2.2
通讯作者：
Barr RG
中科院分区：
文献类型：
--
作者：
McAllister DA;MacNee W;Duprez D;Hoffman EA;Vogel-Claussen J;Criqui MH;Budoff M;Jiang R;Bluemke DA;Barr RG
Forced expiratory volume in one second strongly predicts mortality from cardiovascular disease. FEV1 has been associated with aortic stiffness a strong independent predictor of cardiovascular mortality. However, the anatomical site and possible mechanisms linking aortic stiffness and lung function are unknown. We therefore examined if FEV1 and CT percent emphysema were associated with calcification of the abdominal aorta or reduced distensibility of the proximal thoracic aorta. The Multi-Ethnic Study of Atherosclerosis (MESA) measured aortic calcification on cardiac and abdominal CT scans and proximal aortic distensibility using magnetic resonance among participants aged 45–84 years without clinical cardiovascular disease. Spirometry was measured following ATS/ERS guidelines and percent emphysema was measured in the lung fields of cardiac CT scans. Multivariate analyses adjusted for age, sex, race/ethnicity and cardiovascular risk factors. Of 1,917 participants with aortic distensibility measures, 13% were current and 38% were former smokers. Eighteen percent had airflow limitation without asthma. FEV1 was associated with the extent of distal aortic calcification (0.76; 95%CI 0.60–0.97, p=0.02) but not proximal aortic calcification or proximal aortic distensibility (−0.04 mmHg−1; 95%CI −0.16–0.09 mmHg−1, p=0.60). Percent emphysema was associated with neither measure. FEV1 was associated with severity of distal aortic calcification where it was present independently of smoking and other cardiovascular risk factors but not with distensibility or calcification of the proximal aorta.
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影响因子：
9.6
作者：
Hankinson, John L.;Kawut, Steven M.;Barr, R. Graham
通讯作者：
Barr, R. Graham
影响因子：
6.1
作者：
Guérin, AP;London, GM;Metivier, F
通讯作者：
Metivier, F
影响因子：
9.6
作者：
Chapman, KR;Tashkin, DP;Pye, DJ
通讯作者：
Pye, DJ
影响因子：
39.3
作者：
Erbel, Raimund;Delaney, Joseph A. C.;Lehmann, Nils;McClelland, Robyn L.;Moehlenkamp, Stefan;Kronmal, Richard A.;Schmermund, Axel;Moebus, Susanne;Dragano, Nico;Stang, Andreas;Joeckel, Karl-Heinz;Budoff, Matthew J.
通讯作者：
Budoff, Matthew J.
影响因子：
5
作者：
Jiang, Rui;Burke, Gregory L.;Barr, R. Graham
通讯作者：
Barr, R. Graham