Prevalence of antimicrobial resistance in bacteria isolated from central nervous system specimens as reported by U.S. hospital laboratories from 2000 to 2002.
Prevalence of antimicrobial resistance in bacteria isolated from central nervous system specimens as reported by U.S. hospital laboratories from 2000 to 2002.
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DOI：
10.1186/1476-0711-3-3
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发表时间：
2004-03-25
影响因子：
5.7
通讯作者：
Bradley, John S
中科院分区：
文献类型：
--
作者：
Jones, Mark E;Draghi, Deborah C;Bradley, John S
背景：中枢神经系统的细菌感染，特别是细菌性脑膜炎等急性感染，需要立即进行经验性的抗生素治疗。细菌物种中普遍出现的耐药性令人担忧。目前中枢神经系统(CNS)病原菌的药敏数据对确定当前的耐药流行情况很重要。方法：利用美国监测数据库(TSN)收集美国300家医院实验室的常规药敏数据，分析从中枢神经系统(CNS)标本中分离的病原菌的药敏情况。结果：最常见的革兰阳性菌为金黄色葡萄球菌(23.7%)和肺炎链球菌(11.0%)。革兰氏阴性菌约占分离株的25%。典型的患者年龄为1岁或
BACKGROUND: Bacterial infections of the central nervous system, especially acute infections such as bacterial meningitis require immediate, invariably empiric antibiotic therapy. The widespread emergence of resistance among bacterial species is a cause for concern. Current antibacterial susceptibility data among central nervous system (CNS) pathogens is important to define current prevalence of resistance.METHODS: Antimicrobial susceptibility of pathogens isolated from CNS specimens was analyzed using The Surveillance Database (TSN) USA Database which gathers routine antibiotic susceptibility data from >300 US hospital laboratories. A total of 6029 organisms derived from CNS specimen sources during 2000-2002, were isolated and susceptibility tested.RESULTS: Staphylococcus aureus (23.7%) and Streptococcus pneumoniae (11.0%) were the most common gram-positive pathogens. Gram-negative species comprised approximately 25% of isolates. The modal patient age was 1 or