Sodium thiosulfate solution spray for relief of irritation caused by Lugol's stain in chromoendoscopy
Sodium thiosulfate solution spray for relief of irritation caused by Lugol's stain in chromoendoscopy
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DOI：
10.1067/mge.2001.110730
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发表时间：
2001-02-01
影响因子：
7.7
通讯作者：
Yoshida, S
中科院分区：
文献类型：
--
作者：
Kondo, H;Fukuda, H;Yoshida, S
背景：众所周知，粘蛋白碘染色可提高食管鳞状上皮异型增生和癌的内镜可视化。然而，它经常引起粘膜刺激，导致胸骨后不适。硫代硫酸钠溶液（STS）缓解粘膜染色与卢戈氏液引起的症状的临床实用性进行了评估，在这个study.Methods：120名健康男性在50岁以上的研究。他们均接受了食管胃镜检查，包括在食管中段和远端喷洒Lugol碘溶液（10 mL），随后随机分为三组：（I）未治疗（n = 40），（11）通过内窥镜导管喷洒20 mL氢氧化铝镁凝胶（Maalox）（0 = 40），（III）通过内窥镜导管（0 = 40）喷洒20公吨5%硫代硫酸钠溶液。一个小时后，内窥镜检查的受试者被要求完成一份问卷，解决不良症状引起的卢戈氏碘staining.Results：硫代硫酸钠溶液喷雾大大减少不良症状，持续超过30分钟后chromodendoscopy，与无治疗组相比。Maalox组和未治疗组之间出现症状的受试者比例无显著差异。每次使用硫代硫酸钠溶液喷雾的成本为0.15美元（15日元）。结论：硫代硫酸钠溶液推荐用于卢戈氏染色后的常规使用。
Background: Mucosal iodine staining is known to improve the endoscopic visualization of esophageal squamous dysplasia and cancer. However, it often causes mucosal irritation leading to retrosternal discomfort. The clinical usefulness of sodium thiosulfate solution (STS) for easing symptoms induced by mucosal staining with Lugol's solution was evaluated in this study.Methods: One hundred twenty healthy men over 50 years of age were enrolled in the study. They each underwent esophagogastroscopy including the spraying of Lugol's iodine solution (10 mL) on the mid and distal esophagus and were subsequently randomized into three groups: (I) no treatment (n = 40), (11) spraying of 20 mL of aluminum-magnesium hydroxide gel (Maalox) by means of endoscopic catheter (0 = 40), and (III) spraying of 20 mt of 5% sodium thiosulfate solution by means of endoscopic catheter (0 = 40). An hour after the endoscopic examination the subjects were asked to complete a questionnaire that addressed adverse symptoms induced by Lugol's iodine staining.Results: Sodium thiosulfate solution spray substantially reduced adverse symptoms that lasted more than 30 minutes after chromoendoscopy, compared with the no-treatment group. There was no significant difference in the proportion of subjects with symptoms between the Maalox and no-treatment groups. Cost of sodium thiosulfate solution spray per use was $0.15 (15 yen).Conclusions: Sodium thiosulfate solution is recommended for routine use after Lugol's staining.