Condyloma and intraepithelial neoplasia of the uterine cervix: a case-control study.
Condyloma and intraepithelial neoplasia of the uterine cervix: a case-control study.
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宫颈尖锐湿疣和上皮内瘤变：病例对照研究。
DOI：
10.1093/oxfordjournals.aje.a114973
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发表时间：
1988
影响因子：
5
通讯作者：
A. Meisels
中科院分区：
文献类型：
--
作者：
J. Brisson;M. Roy;M. Fortier;C. Bouchard;A. Meisels
宫颈湿疣和宫颈上皮内瘤变与人乳头瘤病毒感染有关，其中一些可能与宫颈癌的病因有关。这项病例对照研究旨在评估首次性交年龄、性伴侣数量和吸烟与宫颈尖锐湿疣和宫颈上皮内瘤变风险的关系。病例和对照是1982年至1985年间在魁北克圣圣医院阴道镜诊所接受检查的50岁以下绝经前妇女。其中136例经组织学证实的宫颈尖锐湿疣和247例宫颈上皮内瘤变。 137 名对照者是没有肛门生殖器湿疣、发育不良或癌的女性。通过访谈获得有关受试者个人特征和暴露情况的信息。对于尖锐湿疣和宫颈上皮内瘤变，观察到的与首次性交年龄的关联是不同的。尖锐湿疣的相对风险随首次性交年龄的变化变化不大。相反，随着首次性交年龄的降低，宫颈上皮内瘤变的相对风险增加。对于这两种类型的病变，拥有超过一名性伴侣的女性的相对风险较高，并且随着每天吸烟数量的增加而稳步增加。然而，宫颈上皮内瘤变与吸烟的关联性更强。
Cervical condyloma and cervical intraepithelial neoplasia are related to human papillomavirus infections, some of which may be involved in the etiology of cancer of the uterine cervix. This case-control study was designed to assess the relation of age at first sexual intercourse, number of sexual partners, and cigarette smoking to the risk of cervical condyloma and cervical intraepithelial neoplasia. Cases and controls were premenopausal women under age 50 years who had been referred for examination at the Colposcopy Clinic of Saint-Sacrement Hospital in Quebec from 1982 to 1985. These were 136 cases of histologically confirmed cervical condyloma and 247 cases of cervical intraepithelial neoplasia. The 137 controls were women without anogenital condyloma, dysplasia, or carcinoma. Information on personal characteristics and exposures of subjects was obtained by interview. Associations observed with age at first intercourse were different for condyloma and cervical intraepithelial neoplasia. Relative risk of condyloma varied little with age at first intercourse. In contrast, relative risk of cervical intraepithelial neoplasia increased as age at first intercourse decreased. For the two types of lesions, relative risk was elevated among women with more than one sexual partner and increased steadily with increasing number of cigarettes smoked per day. The association with cigarette smoking was, however, somewhat stronger for cervical intraepithelial neoplasia.