Strontium Accumulation by Sarcoplasmic Reticulum and Mitochondria in Vascular Smooth Muscle
Strontium Accumulation by Sarcoplasmic Reticulum and Mitochondria in Vascular Smooth Muscle
复制标题
血管平滑肌肌浆网和线粒体的锶积累
DOI：
10.1126/science.174.4012.955
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发表时间：
1971
期刊：
影响因子：
56.9
通讯作者：
A. Somlyo
中科院分区：
文献类型：
--
作者：
A. Somlyo;A. Somlyo
Electron-opaque deposits of strontium were observed in the sarcoplasmic reticulum and in mitochondria of spontaneously contracting vascular smooth muscles that had been incubated in a strontium-containing solution prior to fixation. The deposits were present in those elements of the sarcoplasmic reticulum that are in close contact with the surface membrane and also in more centrally located portions. In vascular smooth muscle that does not contract spontaneously, similar deposits of strontium were only seen if the muscle was depolarized during or glycerinated before exposure to the strontium-containing solution. Strontium was also deposited in the sarcoplasmic reticulum of the endothelium. It is suggested that translocation of calcium from the sarcoplasmic reticulum that is in close contact with the surface membrane, and now shown to accumulate divalent cations, is responsible for the action potential-triggered contractions of rabbit and guinea pig mesenteric veins. Strontium may also be a suitable marker for identifying sites that accumulate calcium in other types of cells in which translocation of calcium plays a major regulatory function.
