Development of identical orientation maps for two eyes without common visual experience
Development of identical orientation maps for two eyes without common visual experience
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DOI：
10.1038/379251a0
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发表时间：
1996-01-18
期刊：
影响因子：
64.8
通讯作者：
Bonhoeffer, T
中科院分区：
文献类型：
--
作者：
Godecke, I;Bonhoeffer, T
在哺乳动物的视觉皮层中，许多神经元是双眼驱动的，并且两只眼睛的响应特性（如方向偏好或空间频率调谐）几乎相同（1）。为了检测视差，方向的精确匹配是必不可少的，因此是立体视觉的先决条件。目前尚不清楚这种匹配是否是由活动依赖机制与眼睛通常接受的共同视觉体验一起完成的（2，3），或者视觉系统是否依赖于其他，甚至可能是先天的，线索来完成这项任务（4-7）。在这里，我们测试视觉经验是否是负责在一个反向视觉实验中，小猫被提高，使两只眼睛永远无法看到在同一时间的匹配。比较在这些条件下形成的两张地图的布局，发现它们几乎是相同的。考虑到两只眼睛从来没有共同的视觉经验，这表明相关的视觉输入是不需要的取向偏好地图的对齐。
IN the mammalian visual cortex, many neurons are driven binocularly and response properties such as orientation preference or spatial frequency tuning are virtually identical for the two eyes(1). A precise match of orientation is essential in order to detect disparity and is therefore a prerequisite for stereoscopic vision. It is not clear whether this match is accomplished by activity-dependent mechanisms together wit the common visual experience normally received by the eyes(2,3), or whether the visual system relies on other, perhaps even innate, cues to achieve this task(4-7). Here we test whether visual experience is responsible for the match in a reverse-suturing experiment in which kittens were raised so that both eyes were never able to see at the same time. A comparison of the layout of the two maps formed under these conditions showed them to be virtually identical. Considering that the two eyes never had common visual experience, this indicates that correlated visual input is not required for the alignment of orientation preference maps.