Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999-2012).
Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999-2012).
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DOI：
10.1038/srep30373
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发表时间：
2016-07-26
影响因子：
4.6
通讯作者：
Patel CJ
中科院分区：
文献类型：
--
作者：
McGinnis DP;Brownstein JS;Patel CJ
确定与血压相关的环境暴露是当务之急。最近，我们提出了全环境关联研究，以寻找和复制与表型相关的环境因素。我们使用国家健康和营养检查调查(1999-2012)进行了全环境关联研究(Ewas)，评估了总共71,916名参与者，以确定与收缩和舒张压相关的环境因素的优先顺序。我们搜索了1999-2006年调查年参与者的影响因素，并初步复制了2007-2012年参与者的研究结果。最后，我们估计了总体关联性，并使用所有调查年份(1999-2012年)进行了第二次荟萃分析。对于收缩压，自我报告的饮酒成为我们最大的发现(自我报告的酒精每增加1个标准差，收缩压的毫米汞柱增加0.04毫米汞柱)，尽管影响很小。对于舒张压，尿铯是暂时复制的；然而，这一因素在不同人群之间表现出高度的异质性(I2 = 51%)。在如此广泛的分析中缺乏关联性，引发了更广泛地寻找影响血压的环境因素的呼声。
Identifying environmental exposures associated with blood pressure is a priority. Recently, we proposed the environment-wide association study to search for and replicate environmental factors associated with phenotypes. We conducted the environment-wide association study (EWAS) using the National Health and Nutrition Examination Surveys (1999–2012) which evaluated a total of 71,916 participants to prioritize environmental factors associated with systolic and diastolic blood pressure. We searched for factors on participants from survey years 1999–2006 and tentatively replicated findings in participants from years 2007–2012. Finally, we estimated the overall association and performed a second meta-analysis using all survey years (1999–2012). For systolic blood pressure, self-reported alcohol consumption emerged as our top finding (a 0.04 increase in mmHg of systolic blood pressure for 1 standard deviation increase in self-reported alcohol), though the effect size is small. For diastolic blood pressure, urinary cesium was tentatively replicated; however, this factor demonstrated high heterogeneity between populations (I2 = 51%). The lack of associations across this wide of an analysis raises the call for a broader search for environmental factors in blood pressure.