Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture.
Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture.
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Endothelin-3 抑制催乳素并刺激垂体细胞培养物分泌 LH、FSH 和 TSH。
DOI：
10.1016/0006-291x(91)90525-c
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发表时间：
1991
影响因子：
3.1
通讯作者：
Freeman,ME
中科院分区：
文献类型：
--
作者：
Kanyicska,B;Burris,TP;Freeman,ME
在广泛的浓度（从 10−14 到 10−6M）和孵育时间（从 4 到 48 小时）范围内研究了内皮素 3 (ET-3) 对垂体前叶激素分泌的影响。 ET-3 会引起催乳素 (PRL) 分泌的浓度依赖性抑制，并刺激雌性大鼠垂体前叶细胞原代单层培养物中黄体生成素 (LH)、卵泡刺激素 (FSH) 和促甲状腺激素 (TSH) 的释放。不同垂体细胞对ET-3的反应在起效时间和持续时间上存在显着差异：PRL分泌的最大抑制发生在12小时后，LH、FSH和TSH的刺激分别在孵育4、48和48小时后达到最大。这些数据证实了 ET-3 作为神经内分泌调节剂具有重要作用的概念。此外，所提供的数据表明 ET-3 作用的不同细胞内机制。
The influence of endothelin-3 (ET-3) on anterior pituitary hormone secretion was investigated over a wide range of concentrations (from 10−14to 10−6M) and incubation times (from 4 to 48 hours). ET-3 elicited a concentration-dependent inhibition of prolactin (PRL) secretion and stimulated the release of luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH) from primary monolayer cultures of anterior pituitary cells derived from female rats. The responsiveness of different pituitary cells to ET-3 differs markedly in terms of onset and duration: the maximal inhibition of PRL secretion occurred after 12 hours and the stimulation of LH, FSH and TSH reached the maximum after 4, 48 and 48 hours of incubation, respectively. These data corroborate the concept that ET-3 has an important role as a neuroendocrine modulator. Moreover, the data presented suggest different intracellular mechanisms underlying ET-3 actions.