Weight loss and exercise walking reduce pain and improve physical functioning in overweight postmenopausal women with knee osteoarthritis
Weight loss and exercise walking reduce pain and improve physical functioning in overweight postmenopausal women with knee osteoarthritis
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DOI：
10.1097/00124743-200108000-00006
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发表时间：
2001-08-01
影响因子：
3.4
通讯作者：
Hochberg, MC
中科院分区：
文献类型：
--
作者：
Martin, K;Fontaine, KR;Hochberg, MC
我们进行了一项不受控制的初步研究，以确定体重减轻和步行计划对超重和肥胖（体重指数；BMI [kg/m(2)] 25-29.9和BMI分别大于或等于30）绝经后膝关节骨关节炎（OA）妇女膝关节疼痛和身体功能的影响。48名这样的女性完成了自我报告（安大略省西部和麦克马斯特大学骨关节炎指数（WOMAC））和基于表现的身体功能测量（“起身”测试，6分钟步行），并参加了为期6个月的干预，包括每周的营养课程和锻炼步行计划。在完成该计划的30名妇女中，干预产生了5.6 +/-4.0公斤的平均体重减轻。6分钟步行和最大摄氧量也有显著改善。然而，在时间上升和走测试和WOMAC疼痛和功能评分上的改善仅限于基线被归类为肥胖的女性。这些发现表明，6个月的减肥和步行计划可以改善患有膝关节OA的超重和肥胖绝经后妇女的身体功能和疼痛。在肥胖女性中，功能改善与体重减轻相关，鼓励继续强调体重减轻治疗膝关节OA。
We conducted an uncontrolled pilot study to determine the effects of a weight loss and walking program on knee pain and physical function in overweight and obese (body mass index; BMI [kg/m(2)] 25-29.9 and BMI greater than or equal to 30, respectively) postmenopausal women with knee osteoarthritis (OA). Forty-eight such women completed self-report (Western Ontario and McMaster University Osteoarthritis Index (WOMAC)) and performance-based measures of physical function ("up & go" test, 6-min walk) and enrolled in a 6-month intervention that included weekly nutrition classes and an exercise-walking program.The intervention produced an average weight loss of 5.6 +/-4.0 kg in the 30 women who completed the program. There also were significant improvements in the 6-min walk and on VO2max. Improvements in the timed up & go test and on the WOMAC pain and function scores, however, were restricted only to women who were classified as obese at baseline. These findings suggest that a 6-month weight loss and walking program improves measures of physical functioning and pain in overweight and obese postmenopausal women with knee OA. Among obese women, functional improvement correlated with weight loss, encouraging continued emphasis on weight loss for managing knee OA.