Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy.
Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy.
复制标题
脐带药物和可替宁水平与母亲自我报告的怀孕期间吸毒和吸烟情况的一致性。
DOI：
10.1038/jp.2010.132
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Collier,AC
中科院分区：
文献类型：
--
作者：
Wright,TE;Milam,KA;Rougee,L;Tanaka,MD;Collier,AC
目的：我们进行了这项研究，以评估胎儿脐带药物水平和产妇self-report.Study设计：脐带样本收集103胎盘分娩后作为一个子项目的太平洋研究中心早期人类发育（PRCEHD）研究之间的协议。然后对这些脐带样本进行处理以获得脐带裂解物，并对可替宁和非法药物进行酶联免疫吸附测定（ELISA）。结果：我们发现自我报告的吸烟和可替宁水平之间存在公平的一致性（κ= 0.26（0.07至0.5）），并且与当前药物使用和阳性药物水平略有一致性（κ= 0.19（-0.05至0.4））。与母亲自报相比，可替宁水平的敏感性为27%，特异性为98%。结论：脐带血中违禁药物浓度检测的敏感性为32%，特异性为85%。据我们所知，这是第一项测量脐带组织中可替宁水平的研究。
Objective:We undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report.Study Design:Cord samples were collected from 103 placentas after delivery as a subproject of the larger Pacific Research Center for Early Human Development (PRCEHD) study. These cord samples were then processed to obtain cord lysates and enzyme-linked immunosorbent assay (ELISA) performed for cotinine and illicit drugs. Levels of each of these substances were compared with clinical information.Result:We found fair agreement between self-reported smoking and cotinine levels (κ= 0.26 (0.07 to 0.5)) as well as slight agreement with current drug use and positive drug levels (κ= 0.19 (− 0.05 to 0.4)). Compared with maternal self-report, sensitivity of cotinine levels was 27% and specificity was 98%. Sensitivity of positive cord illicit drug levels was 32% and specificity was 85%.Conclusion:Umbilical cords provide another independent measure of maternal drug use and are readily available. To our knowledge, this is the first study to measure cotinine levels in the umbilical cord tissue.