DEMONSTRATION OF IMMUNOGLOBULIN IN THE NEIGHBORHOOD OF ADVANCED ATHEROSCLEROTIC PLAQUES
DEMONSTRATION OF IMMUNOGLOBULIN IN THE NEIGHBORHOOD OF ADVANCED ATHEROSCLEROTIC PLAQUES
复制标题
DOI：
10.1016/0021-9150(81)90118-0
复制
发表时间：
1981-01-01
期刊：
影响因子：
5.3
通讯作者：
MITCHINSON, MJ
中科院分区：
文献类型：
--
作者：
PARUMS, D;MITCHINSON, MJ
对与动脉粥样硬化相关的炎症细胞浸润的尸检调查表明，炎症程度与动脉粥样硬化斑块的严重程度相关，并且在存在内侧破坏的情况下炎症程度更大。使用免疫过氧化物酶技术对切片进行 IgG 和 IgM 染色。具有内侧破坏的晚期斑块显示外膜中浆细胞的细胞质被 IgG 和 IgM 抗血清染色。在动脉粥样化材料中证实了 IgG。 Ig 的产生可能会受到晚期病变中形成的抗原的刺激。这种过敏反应可能可以解释晚期[人类]动脉粥样硬化的一些并发症。
A necropsy survey of inflammatory cellular infiltration associated with atherosclerosis showed that the degree of inflammation correlated with the severity of the atherosclerotic plaque and was greater in the presence of medial disruption. Sections were stained for IgG and IgM using the immunoperoxidase technique. Advanced plaques with medial disruption showed staining of the cytoplasm of plasma cells in the adventitia with IgG and IgM antisera. IgG was demonstrated in the atheromatous material. The Ig production may be stimulated by antigens formed in the advanced lesion. Such an allergic reaction might explain some complications of advanced [human] atherosclerosis.