Therapeutic time window of methylprednisolone in acoustic injury
Therapeutic time window of methylprednisolone in acoustic injury
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DOI：
10.1097/01.mao.0000226313.82069.3f
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发表时间：
2006-12-01
影响因子：
2.1
通讯作者：
Hara, Akira
中科院分区：
文献类型：
--
作者：
Tabuchi, Keiji;Murashita, Hidekazu;Hara, Akira
假设：本研究旨在探讨甲基强的松龙在声损伤中的治疗时间窗，背景：糖皮质激素已被广泛应用于治疗声损伤，但糖皮质激素在声损伤中的治疗时间窗尚未被研究。结果：甲基强的松龙在声刺激前或声刺激后即刻给药，可明显改善声刺激后2周的听性脑干反应阈移，但在声刺激后3h给药，对听性脑干反应阈移无明显影响。目前的研究结果表明，甲基强的松龙具有保护作用，对听觉损伤的耳蜗与较短的治疗时间窗。
Hypothesis: This study aims to investigate the therapeutic time window of methylprednisolone in acoustic injury.Background: Although glucocorticoids have been widely used in the treatment of acoustic injury, the therapeutic time window of glucocorticoids in acoustic injury has never been examined.Methods: Mice were exposed to 4-kHz pure tone of 128-dB sound pressure level for 4 hours. Auditory brainstem response was examined before, immediately after, and 2 weeks after acoustic overexposure.Results: Methylprednisolone significantly improved the auditory brainstem response threshold shifts 2 weeks after acoustic overexposure when it was administered before or immediately after acoustic overexposure, but not when administered 3 hours after acoustic overexposure.Conclusion: The present findings suggest that methylprednisolone possesses protective effects against acoustic injury of the cochlea with a short therapeutic time window.