Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion
Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion
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DOI：
10.1179/2045772312y.0000000028
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发表时间：
2013-03-01
影响因子：
1.7
通讯作者：
Zhang, Wei
中科院分区：
文献类型：
--
作者：
Liu, Zhi-Qiang;Xing, Shan-Shan;Zhang, Wei
背景资料：脊髓缺血/再灌注损伤（Ischemic/reperfusion injury，I/R）是胸腹主动脉手术后的严重并发症，目的：探讨姜黄素对脊髓缺血/再灌注损伤的保护作用。家兔主动脉阻断30分钟，诱导短暂的脊髓缺血。再灌注后观察神经功能恢复情况，取L3 ~ L5脊髓节段进行组织病理学检查。结果：I/R组动物致截瘫后，脊髓组织中丙二醛（MDA）、超氧化物歧化酶（SOD）活性明显升高。治疗48 h后，与I/R组相比，姜黄素组神经功能明显改善，细胞凋亡减少，MDA水平降低，SOD活性升高（P < 0.05）。结论：结果表明，至少在动物模型中，姜黄素可以通过减少氧化损伤，这可能为脊髓缺血性损伤的治疗提供新的途径。
Background: Ischemic/reperfusion (I/R) injury of the spinal cord is a serious complication that can result from thoracoabdominal aortic surgery.Objective: To investigate the neuroprotective effect of curcumin against I/R injury in a rabbit model.Methods: A total of 36 rabbits were randomly divided into three groups: sham, I/R, and curcumin-treated group. Rabbits were subject to 30-min aortic occlusion to induce transient spinal cord ischemia. Neurological function was observed after reperfusion and spinal cord segment (L3-L5) was collected for histopathological evaluation. Malondialdehyde (MDA) and total superoxide dismutase (SOD) activity were also assayed.Results: Rabbits in I/R group were induced to paraplegia. While after 48-hour treatment, compared with I/R group, curcumin significantly improved neurological function, reduced cell apoptosis and MDA levels as well as increased SOD activity (P < 0.05).Conclusions: The results suggest that curcumin, at least in an animal model, can attenuate transient spinal cord ischemic injury potentially via reducing oxidative damage, which may provide a novel approach in the treatment of spinal cord ischemic injury.